BRD-K12787259_CX-5461_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K12787259_CX-5461_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOA aldolase A, fructose-bisphosphate
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
C8ORF4 chromosome 8 open reading frame 4
CAPN6 calpain 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL4A5 collagen, type IV, alpha 5
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DFNA5 deafness, autosomal dominant 5
DUSP6 dual specificity phosphatase 6
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
GABARAPL1 GABA(A) receptor-associated protein like 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
ICAM2 intercellular adhesion molecule 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KYNU kynureninase
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFSD10 major facilitator superfamily domain containing 10
MIR22HG MIR22 host gene
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON2 paraoxonase 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PSD3 pleckstrin and Sec7 domain containing 3
RPS27L ribosomal protein S27-like
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ALOX5 arachidonate 5-lipoxygenase
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD1E CD1e molecule
CD2 CD2 molecule
CD8A CD8a molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DICER1 dicer 1, ribonuclease type III
DPYD dihydropyrimidine dehydrogenase
EPHX2 epoxide hydrolase 2, cytoplasmic
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FASTKD3 FAST kinase domains 3
GBP1 guanylate binding protein 1, interferon-inducible
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IPO13 importin 13
ISL1 ISL LIM homeobox 1
JCHAIN joining chain of multimeric IgA and IgM
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MMP2 matrix metallopeptidase 2
MSH6 mutS homolog 6
MYO1B myosin IB
NKX3-1 NK3 homeobox 1
PAPD7 PAP associated domain containing 7
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PRKD3 protein kinase D3
PXMP2 peroxisomal membrane protein 2, 22kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAT1 signal transducer and activator of transcription 1, 91kDa
TCF4 transcription factor 4
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TPSAB1 tryptase alpha/beta 1