BRD-K12539581_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K12539581_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADRB2 adrenoceptor beta 2, surface
AKAP8 A kinase (PRKA) anchor protein 8
ALCAM activated leukocyte cell adhesion molecule
AQP3 aquaporin 3 (Gill blood group)
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BHLHE40 basic helix-loop-helix family, member e40
C8ORF4 chromosome 8 open reading frame 4
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CHIC2 cysteine-rich hydrophobic domain 2
CLTB clathrin, light chain B
CORO1C coronin, actin binding protein, 1C
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
ELL2 elongation factor, RNA polymerase II, 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GOLIM4 golgi integral membrane protein 4
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSPT1 G1 to S phase transition 1
HBEGF heparin-binding EGF-like growth factor
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
ILK integrin-linked kinase
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JMJD1C jumonji domain containing 1C
KIAA0355 KIAA0355
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MEGF9 multiple EGF-like-domains 9
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PALLD palladin, cytoskeletal associated protein
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKM pyruvate kinase, muscle
PLAU plasminogen activator, urokinase
POSTN periostin, osteoblast specific factor
PRNP prion protein
RALB v-ral simian leukemia viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SMAD3 SMAD family member 3
SMC1A structural maintenance of chromosomes 1A
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TOMM34 translocase of outer mitochondrial membrane 34
TSC22D2 TSC22 domain family, member 2
VNN1 vanin 1
WDR1 WD repeat domain 1
ZYX zyxin

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ALOX5 arachidonate 5-lipoxygenase
BCAM basal cell adhesion molecule (Lutheran blood group)
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CFB complement factor B
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLU clusterin
COL15A1 collagen, type XV, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
DSG2 desmoglein 2
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
GREB1 growth regulation by estrogen in breast cancer 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
LPAR6 lysophosphatidic acid receptor 6
MAOB monoamine oxidase B
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MTUS1 microtubule associated tumor suppressor 1
MUC16 mucin 16, cell surface associated
NR2F6 nuclear receptor subfamily 2, group F, member 6
OPHN1 oligophrenin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLIN1 perilipin 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PXDN peroxidasin
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM14B transmembrane protein 14B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRPS1 trichorhinophalangeal syndrome I
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2