BRD-K12539581_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K12539581_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADRB2 adrenoceptor beta 2, surface
AHNAK AHNAK nucleoprotein
AK4 adenylate kinase 4
ALB albumin
APOA2 apolipoprotein A-II
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
BIK BCL2-interacting killer (apoptosis-inducing)
BTG3 BTG family, member 3
CBS cystathionine-beta-synthase
CBX1 chromobox homolog 1
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COBL cordon-bleu WH2 repeat protein
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1 eukaryotic translation initiation factor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
GADD45B growth arrest and DNA-damage-inducible, beta
GLIPR1 GLI pathogenesis-related 1
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLM1 golgi membrane protein 1
GSTM3 glutathione S-transferase mu 3 (brain)
HOPX HOP homeobox
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
NEK3 NIMA-related kinase 3
NOTCH2NL notch 2 N-terminal like
OGN osteoglycin
ORM1 orosomucoid 1
PALLD palladin, cytoskeletal associated protein
PDGFA platelet-derived growth factor alpha polypeptide
PPT1 palmitoyl-protein thioesterase 1
PRSS2 protease, serine, 2 (trypsin 2)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
REEP1 receptor accessory protein 1
RPL10 ribosomal protein L10
RTN1 reticulon 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNX11 sorting nexin 11
SORBS2 sorbin and SH3 domain containing 2
SOX11 SRY (sex determining region Y)-box 11
STS steroid sulfatase (microsomal), isozyme S
SYBU syntabulin (syntaxin-interacting)
TFRC transferrin receptor

decreased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BAMBI BMP and activin membrane-bound inhibitor
CCNF cyclin F
CD24 CD24 molecule
COL15A1 collagen, type XV, alpha 1
CRISP3 cysteine-rich secretory protein 3
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EML3 echinoderm microtubule associated protein like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM129A family with sequence similarity 129, member A
FZD7 frizzled class receptor 7
GDF15 growth differentiation factor 15
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP4 insulin-like growth factor binding protein 4
MARCKSL1 MARCKS-like 1
MGAM maltase-glucoamylase
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NOTCH3 notch 3
NTS neurotensin
POPDC3 popeye domain containing 3
PRAME preferentially expressed antigen in melanoma
PSIP1 PC4 and SFRS1 interacting protein 1
RRAGD Ras-related GTP binding D
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPRR1A small proline-rich protein 1A
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TMX4 thioredoxin-related transmembrane protein 4
UPK1B uroplakin 1B
VCAM1 vascular cell adhesion molecule 1