BRD-K12516989_Zaprinast_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K12516989_Zaprinast_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA2 annexin A2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARID1A AT rich interactive domain 1A (SWI-like)
ARMCX1 armadillo repeat containing, X-linked 1
ATP10D ATPase, class V, type 10D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
BEX4 brain expressed, X-linked 4
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK14 cyclin-dependent kinase 14
CDK4 cyclin-dependent kinase 4
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
COG7 component of oligomeric golgi complex 7
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CXCR4 chemokine (C-X-C motif) receptor 4
DENND1B DENN/MADD domain containing 1B
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
ESM1 endothelial cell-specific molecule 1
EXT1 exostosin glycosyltransferase 1
FASN fatty acid synthase
FCHO1 FCH domain only 1
FHOD3 formin homology 2 domain containing 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA4 golgin A4
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
H2AFV H2A histone family, member V
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCTD12 potassium channel tetramerization domain containing 12
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MEST mesoderm specific transcript
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MTERF3 mitochondrial transcription termination factor 3
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOX4 NADPH oxidase 4
NPIPB3 nuclear pore complex interacting protein family, member B3
NVL nuclear VCP-like
OPN3 opsin 3
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMM2 phosphomannomutase 2
PON3 paraoxonase 3
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RAD21 RAD21 homolog (S. pombe)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY4 sprouty homolog 4 (Drosophila)
SULF1 sulfatase 1
TCF4 transcription factor 4
TCTA T-cell leukemia translocation altered
TFEC transcription factor EC
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN31 tetraspanin 31
TSPAN7 tetraspanin 7
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF264 zinc finger protein 264
ZNF274 zinc finger protein 274
ZNF395 zinc finger protein 395
ZNF544 zinc finger protein 544

decreased expression

Symbol Name
AGR2 anterior gradient 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BAG2 BCL2-associated athanogene 2
CALB1 calbindin 1, 28kDa
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND2 cyclin D2
CDA cytidine deaminase
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHL1 cell adhesion molecule L1-like
CNR1 cannabinoid receptor 1 (brain)
COL9A3 collagen, type IX, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSB cathepsin B
CTSC cathepsin C
CYBA cytochrome b-245, alpha polypeptide
DAXX death-domain associated protein
DIRAS3 DIRAS family, GTP-binding RAS-like 3
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPN2 epsin 2
ERGIC2 ERGIC and golgi 2
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FAM222B family with sequence similarity 222, member B
G0S2 G0/G1 switch 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GPM6A glycoprotein M6A
HN1 hematological and neurological expressed 1
ITGB1BP1 integrin beta 1 binding protein 1
MAB21L2 mab-21-like 2 (C. elegans)
MT1F metallothionein 1F
NFIB nuclear factor I/B
NGRN neugrin, neurite outgrowth associated
NPY neuropeptide Y
PCDH9 protocadherin 9
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCZ protein kinase C, zeta
PRSS2 protease, serine, 2 (trypsin 2)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SET SET nuclear proto-oncogene
SORBS1 sorbin and SH3 domain containing 1
SPRR3 small proline-rich protein 3
SUB1 SUB1 homolog (S. cerevisiae)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TSPAN8 tetraspanin 8
ZCCHC24 zinc finger, CCHC domain containing 24