BRD-K12502280_TG101348_THP1_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K12502280_TG101348_THP1_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASS1 argininosuccinate synthase 1
BHLHE41 basic helix-loop-helix family, member e41
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHN1 chimerin 1
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOCK9 dedicator of cytokinesis 9
DST dystonin
EGFL6 EGF-like-domain, multiple 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FBLN1 fibulin 1
FOXO1 forkhead box O1
GJA1 gap junction protein, alpha 1, 43kDa
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H1C histone cluster 1, H1c
INSIG1 insulin induced gene 1
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LAMB1 laminin, beta 1
LUM lumican
MALL mal, T-cell differentiation protein-like
MAN2A1 mannosidase, alpha, class 2A, member 1
MATN2 matrilin 2
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
METTL7A methyltransferase like 7A
PEG10 paternally expressed 10
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SSPN sarcospan
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPD52L1 tumor protein D52-like 1
TSPAN5 tetraspanin 5
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKAP7 A kinase (PRKA) anchor protein 7
ARHGAP15 Rho GTPase activating protein 15
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
AZU1 azurocidin 1
BMP2 bone morphogenetic protein 2
C8ORF4 chromosome 8 open reading frame 4
CAPN2 calpain 2, (m/II) large subunit
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLEC11A C-type lectin domain family 11, member A
CST3 cystatin C
CTPS1 CTP synthase 1
CXCR4 chemokine (C-X-C motif) receptor 4
DERA deoxyribose-phosphate aldolase (putative)
EFHD2 EF-hand domain family, member D2
ELANE elastase, neutrophil expressed
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GTF3A general transcription factor IIIA
IFRD2 interferon-related developmental regulator 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INTS3 integrator complex subunit 3
IRS2 insulin receptor substrate 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LMO4 LIM domain only 4
LYST lysosomal trafficking regulator
MCUR1 mitochondrial calcium uniporter regulator 1
MMP7 matrix metallopeptidase 7
MNDA myeloid cell nuclear differentiation antigen
MYC v-myc avian myelocytomatosis viral oncogene homolog
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PGAM1 phosphoglycerate mutase 1 (brain)
PLAC8 placenta-specific 8
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRKCB protein kinase C, beta
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SGK1 serum/glucocorticoid regulated kinase 1
SORBS3 sorbin and SH3 domain containing 3
SPRY2 sprouty homolog 2 (Drosophila)
TARBP1 TAR (HIV-1) RNA binding protein 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TRAF3IP3 TRAF3 interacting protein 3
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPO translocator protein (18kDa)
YBX3 Y box binding protein 3