BRD-K12502280_TG-101348_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K12502280_TG-101348_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2 B-cell CLL/lymphoma 2
BEX1 brain expressed, X-linked 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CA11 carbonic anhydrase XI
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLCN4 chloride channel, voltage-sensitive 4
CLDN10 claudin 10
CLGN calmegin
CREG1 cellular repressor of E1A-stimulated genes 1
CTGF connective tissue growth factor
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EMX2 empty spiracles homeobox 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FBLN2 fibulin 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FZD10 frizzled class receptor 10
GAS6 growth arrest-specific 6
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HOMER2 homer scaffolding protein 2
IFI6 interferon, alpha-inducible protein 6
IL6ST interleukin 6 signal transducer
KRT23 keratin 23, type I
LCN2 lipocalin 2
MAGED2 melanoma antigen family D2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MATN2 matrilin 2
OLFM1 olfactomedin 1
PHGDH phosphoglycerate dehydrogenase
PIP prolactin-induced protein
PLA1A phospholipase A1 member A
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEK pleckstrin
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RAB4A RAB4A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RPL37A ribosomal protein L37a
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAP2 signal transducing adaptor family member 2
STMN2 stathmin 2
STOM stomatin
TFPI2 tissue factor pathway inhibitor 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
WASF3 WAS protein family, member 3
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ANXA1 annexin A1
AREG amphiregulin
ATF5 activating transcription factor 5
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL9 chemokine (C-X-C motif) ligand 9
DPYD dihydropyrimidine dehydrogenase
EGR2 early growth response 2
EREG epiregulin
EXOSC4 exosome component 4
F12 coagulation factor XII (Hageman factor)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBE1 hemoglobin, epsilon 1
HIC2 hypermethylated in cancer 2
HIRA histone cell cycle regulator
HSPA14 heat shock 70kDa protein 14
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
LDHB lactate dehydrogenase B
LMNB1 lamin B1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGEB2 melanoma antigen family B2
MCM10 minichromosome maintenance complex component 10
MRPL16 mitochondrial ribosomal protein L16
MTPAP mitochondrial poly(A) polymerase
MYOF myoferlin
NOP16 NOP16 nucleolar protein
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFKP phosphofructokinase, platelet
PLBD1 phospholipase B domain containing 1
PLN phospholamban
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POSTN periostin, osteoblast specific factor
PRPF19 pre-mRNA processing factor 19
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD23B RAD23 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
RCC1 regulator of chromosome condensation 1
RGS2 regulator of G-protein signaling 2
RPP38 ribonuclease P/MRP 38kDa subunit
S100A10 S100 calcium binding protein A10
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TPR translocated promoter region, nuclear basket protein
UFD1L ubiquitin fusion degradation 1 like (yeast)