BRD-K12502280_TG-101348_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K12502280_TG-101348_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADI1 acireductone dioxygenase 1
AUTS2 autism susceptibility candidate 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DUSP22 dual specificity phosphatase 22
FBN2 fibrillin 2
FOXO4 forkhead box O4
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HYOU1 hypoxia up-regulated 1
LAGE3 L antigen family, member 3
LRRC17 leucine rich repeat containing 17
MN1 meningioma (disrupted in balanced translocation) 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PEG3 paternally expressed 3
RAB4A RAB4A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RPL31 ribosomal protein L31
SEPP1 selenoprotein P, plasma, 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TBL1X transducin (beta)-like 1X-linked
TMSB15A thymosin beta 15a
VNN1 vanin 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CRISP3 cysteine-rich secretory protein 3
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
E2F2 E2F transcription factor 2
FOXM1 forkhead box M1
GBP1 guanylate binding protein 1, interferon-inducible
HSPA2 heat shock 70kDa protein 2
KIF1BP KIF1 binding protein
KRT7 keratin 7, type II
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MELK maternal embryonic leucine zipper kinase
MMP7 matrix metallopeptidase 7
MYH11 myosin, heavy chain 11, smooth muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRC1 protein regulator of cytokinesis 1
PRSS23 protease, serine, 23
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A11 S100 calcium binding protein A11
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SORBS1 sorbin and SH3 domain containing 1
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2