BRD-K12502280_TG-101348_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K12502280_TG-101348_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL1 acyl-CoA synthetase long-chain family member 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARS cysteinyl-tRNA synthetase
CCPG1 cell cycle progression 1
CD14 CD14 molecule
CD163 CD163 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSB cathepsin B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FTH1 ferritin, heavy polypeptide 1
GRB10 growth factor receptor-bound protein 10
GRN granulin
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
ITGA10 integrin, alpha 10
KRT5 keratin 5, type II
LCN2 lipocalin 2
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFN2 profilin 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
SARS seryl-tRNA synthetase
SCPEP1 serine carboxypeptidase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SQSTM1 sequestosome 1
STXBP1 syntaxin binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AHSG alpha-2-HS-glycoprotein
APOA2 apolipoprotein A-II
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1L dynamin 1-like
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FST follistatin
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HEPH hephaestin
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LIG1 ligase I, DNA, ATP-dependent
LPAR1 lysophosphatidic acid receptor 1
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MT1M metallothionein 1M
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RBP4 retinol binding protein 4, plasma
RCAN1 regulator of calcineurin 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SPAG5 sperm associated antigen 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFDP1 transcription factor Dp-1
TFPI2 tissue factor pathway inhibitor 2
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRBC1 T cell receptor beta constant 1
TSPAN8 tetraspanin 8
TTK TTK protein kinase
TYMS thymidylate synthetase
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein