BRD-K12393722_1-benzhydryl-4-[(5-methyl-4-nitroisoxazol-3-yl)carbonyl]piperazine BRD-K12393722_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K12393722_1-benzhydryl-4-[(5-methyl-4-nitroisoxazol-3-yl)carbonyl]piperazine BRD-K12393722_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AK4 adenylate kinase 4
AKAP13 A kinase (PRKA) anchor protein 13
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
EVI2A ecotropic viral integration site 2A
FABP4 fatty acid binding protein 4, adipocyte
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GAL galanin/GMAP prepropeptide
GAREM GRB2 associated, regulator of MAPK1
GDF15 growth differentiation factor 15
GFOD1 glucose-fructose oxidoreductase domain containing 1
GPI glucose-6-phosphate isomerase
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LAPTM5 lysosomal protein transmembrane 5
LOC100272216 uncharacterized LOC100272216
MB myoglobin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEG3 maternally expressed 3 (non-protein coding)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP3 matrix metallopeptidase 3
MT1F metallothionein 1F
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEB nebulin
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDE2A phosphodiesterase 2A, cGMP-stimulated
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCB protein kinase C, beta
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TCEAL2 transcription elongation factor A (SII)-like 2
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF292 zinc finger protein 292
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
DCPS decapping enzyme, scavenger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXA5 homeobox A5
IFI44L interferon-induced protein 44-like
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
MARCKS myristoylated alanine-rich protein kinase C substrate
MTCL1 microtubule crosslinking factor 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM5 PDZ and LIM domain 5
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRPF4 pre-mRNA processing factor 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SPRR1B small proline-rich protein 1B
THBS1 thrombospondin 1
U2AF1 U2 small nuclear RNA auxiliary factor 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)