BRD-K12393722_1-benzhydryl-4-[(5-methyl-4-nitroisoxazol-3-yl)carbonyl]piperazine BRD-K12393722_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K12393722_1-benzhydryl-4-[(5-methyl-4-nitroisoxazol-3-yl)carbonyl]piperazine BRD-K12393722_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CFD complement factor D (adipsin)
CSRP1 cysteine and glycine-rich protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
MAOB monoamine oxidase B
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MT1M metallothionein 1M
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYH11 myosin, heavy chain 11, smooth muscle
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PPAP2B phosphatidic acid phosphatase type 2B
RHOB ras homolog family member B
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
VWF von Willebrand factor
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
CD58 CD58 molecule
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
FAP fibroblast activation protein, alpha
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b