BRD-K12343256_trametinib_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K12343256_trametinib_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
APOC1 apolipoprotein C-I
C2CD2 C2 calcium-dependent domain containing 2
CHMP4A charged multivesicular body protein 4A
COCH cochlin
CPA3 carboxypeptidase A3 (mast cell)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSH cathepsin H
DAPK1 death-associated protein kinase 1
EFS embryonal Fyn-associated substrate
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBLN1 fibulin 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPER1 G protein-coupled estrogen receptor 1
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2BG histone cluster 1, H2bg
HOXC10 homeobox C10
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2C integral membrane protein 2C
KRT6A keratin 6A, type II
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
MUC4 mucin 4, cell surface associated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PCP4 Purkinje cell protein 4
PDZK1IP1 PDZK1 interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PENK proenkephalin
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
RBP1 retinol binding protein 1, cellular
RXRA retinoid X receptor, alpha
S100A7 S100 calcium binding protein A7
SPRR1B small proline-rich protein 1B
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)

decreased expression

Symbol Name
AREG amphiregulin
CCND1 cyclin D1
CFH complement factor H
CTGF connective tissue growth factor
CXCL11 chemokine (C-X-C motif) ligand 11
E2F2 E2F transcription factor 2
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA3 EPH receptor A3
EREG epiregulin
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FN1 fibronectin 1
GBP1 guanylate binding protein 1, interferon-inducible
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCTD12 potassium channel tetramerization domain containing 12
KRT23 keratin 23, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MT1X metallothionein 1X
MYOF myoferlin
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PTN pleiotrophin
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TF transferrin
TRIB2 tribbles pseudokinase 2
VCAN versican
VCL vinculin