BRD-K12343256_trametinib_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K12343256_trametinib_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BTG2 BTG family, member 2
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
COL1A1 collagen, type I, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FAM46A family with sequence similarity 46, member A
FILIP1L filamin A interacting protein 1-like
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
GATA6 GATA binding protein 6
GLS glutaminase
GPC1 glypican 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSN gelsolin
GSTT1 glutathione S-transferase theta 1
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
INSR insulin receptor
ITGAV integrin, alpha V
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100505650 uncharacterized LOC100505650
MAP1A microtubule-associated protein 1A
MYL9 myosin, light chain 9, regulatory
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM1 PDZ and LIM domain 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2A phosphatidic acid phosphatase type 2A
PTPRM protein tyrosine phosphatase, receptor type, M
RHOB ras homolog family member B
RHOQ ras homolog family member Q
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
THBS2 thrombospondin 2
TLE4 transducin-like enhancer of split 4
TMEM47 transmembrane protein 47
TNNC1 troponin C type 1 (slow)
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WBP1L WW domain binding protein 1-like
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANO1 anoctamin 1, calcium activated chloride channel
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETV1 ets variant 1
ETV5 ets variant 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
HBEGF heparin-binding EGF-like growth factor
HMGA1 high mobility group AT-hook 1
ICMT isoprenylcysteine carboxyl methyltransferase
IGHD immunoglobulin heavy constant delta
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KRT15 keratin 15, type I
KRT6A keratin 6A, type II
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRKCH protein kinase C, eta
PRMT1 protein arginine methyltransferase 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TGFA transforming growth factor, alpha
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein