BRD-K12343256_trametinib_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K12343256_trametinib_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARID5B AT rich interactive domain 5B (MRF1-like)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAMBI BMP and activin membrane-bound inhibitor
BCAM basal cell adhesion molecule (Lutheran blood group)
BLVRB biliverdin reductase B
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DHCR24 24-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
FADS3 fatty acid desaturase 3
FBLN1 fibulin 1
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
GPC1 glypican 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
HBP1 HMG-box transcription factor 1
HEG1 heart development protein with EGF-like domains 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
KRT18 keratin 18, type I
LCN2 lipocalin 2
LOX lysyl oxidase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
METTL7A methyltransferase like 7A
MSLN mesothelin
MSMO1 methylsterol monooxygenase 1
MUC1 mucin 1, cell surface associated
NEU1 sialidase 1 (lysosomal sialidase)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OBSL1 obscurin-like 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL9 oxysterol binding protein-like 9
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM1 PDZ and LIM domain 1
PLBD1 phospholipase B domain containing 1
PRKCI protein kinase C, iota
PSG5 pregnancy specific beta-1-glycoprotein 5
PTGIS prostaglandin I2 (prostacyclin) synthase
QPRT quinolinate phosphoribosyltransferase
RHOB ras homolog family member B
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STON1 stonin 1
TAGLN transgelin
TMEM135 transmembrane protein 135
TNS1 tensin 1
TPM1 tropomyosin 1 (alpha)
WT1 Wilms tumor 1
YPEL5 yippee-like 5 (Drosophila)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ETV1 ets variant 1
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGB2 high mobility group box 2
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MT1E metallothionein 1E
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RRM2 ribonucleotide reductase M2
S100B S100 calcium binding protein B
SCML1 sex comb on midleg-like 1 (Drosophila)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIPIN TIMELESS interacting protein
TOP2A topoisomerase (DNA) II alpha 170kDa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein