BRD-K12343256_trametinib_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K12343256_trametinib_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BECN1 beclin 1, autophagy related
BEX1 brain expressed, X-linked 1
C1ORF115 chromosome 1 open reading frame 115
CA12 carbonic anhydrase XII
CD163 CD163 molecule
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFB complement factor B
CHI3L2 chitinase 3-like 2
CHL1 cell adhesion molecule L1-like
CHMP4A charged multivesicular body protein 4A
CHPT1 choline phosphotransferase 1
CIDEB cell death-inducing DFFA-like effector b
CNN3 calponin 3, acidic
CNPY3 canopy FGF signaling regulator 3
COCH cochlin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DFNA5 deafness, autosomal dominant 5
DNM1 dynamin 1
EIF4B eukaryotic translation initiation factor 4B
EML3 echinoderm microtubule associated protein like 3
ENO2 enolase 2 (gamma, neuronal)
FGFR4 fibroblast growth factor receptor 4
FOLR1 folate receptor 1 (adult)
GCLC glutamate-cysteine ligase, catalytic subunit
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPC3 glypican 3
GPRC5B G protein-coupled receptor, class C, group 5, member B
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSPA2 heat shock 70kDa protein 2
IFI6 interferon, alpha-inducible protein 6
IGHMBP2 immunoglobulin mu binding protein 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT10 keratin 10, type I
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LMO4 LIM domain only 4
LTF lactotransferrin
LYST lysosomal trafficking regulator
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSRA methionine sulfoxide reductase A
MTSS1 metastasis suppressor 1
NNT nicotinamide nucleotide transhydrogenase
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
OXSR1 oxidative stress responsive 1
PDZK1IP1 PDZK1 interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PENK proenkephalin
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRAME preferentially expressed antigen in melanoma
PRSS23 protease, serine, 23
PRUNE prune exopolyphosphatase
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOA ras homolog family member A
S100A7 S100 calcium binding protein A7
SCRN1 secernin 1
SDC2 syndecan 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPEN spen family transcriptional repressor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSBP2 single-stranded DNA binding protein 2
STC2 stanniocalcin 2
SYNGR3 synaptogyrin 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIK TRAF2 and NCK interacting kinase
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIO trio Rho guanine nucleotide exchange factor
UBL3 ubiquitin-like 3
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
AOX1 aldehyde oxidase 1
AREG amphiregulin
ATM ATM serine/threonine kinase
C7 complement component 7
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDV3 CDV3 homolog (mouse)
CHGB chromogranin B
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COL10A1 collagen, type X, alpha 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
FABP4 fatty acid binding protein 4, adipocyte
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FRZB frizzled-related protein
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HHEX hematopoietically expressed homeobox
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
ISOC1 isochorismatase domain containing 1
LAMB1 laminin, beta 1
LGALS4 lectin, galactoside-binding, soluble, 4
LTBP1 latent transforming growth factor beta binding protein 1
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MYOF myoferlin
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PROCR protein C receptor, endothelial
PROSC proline synthetase co-transcribed homolog (bacterial)
PTHLH parathyroid hormone-like hormone
PUS7 pseudouridylate synthase 7 (putative)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS5 regulator of G-protein signaling 5
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SFRP1 secreted frizzled-related protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNAP25 synaptosomal-associated protein, 25kDa
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STOM stomatin
TFF1 trefoil factor 1
THBS1 thrombospondin 1
U2AF1 U2 small nuclear RNA auxiliary factor 1
VCAN versican
XBP1 X-box binding protein 1