BRD-K12343256_trametinib_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K12343256_trametinib_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOA1 apolipoprotein A-I
APOH apolipoprotein H (beta-2-glycoprotein I)
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
CADM1 cell adhesion molecule 1
CAPN3 calpain 3, (p94)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLDN10 claudin 10
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOK5 docking protein 5
FOLR1 folate receptor 1 (adult)
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6B glycoprotein M6B
GSTA1 glutathione S-transferase alpha 1
H1F0 H1 histone family, member 0
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IQGAP2 IQ motif containing GTPase activating protein 2
ITM2C integral membrane protein 2C
KAZN kazrin, periplakin interacting protein
KIF5C kinesin family member 5C
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC100505650 uncharacterized LOC100505650
MATN2 matrilin 2
MT1E metallothionein 1E
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PON2 paraoxonase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBPMS RNA binding protein with multiple splicing
RGS1 regulator of G-protein signaling 1
RPL37A ribosomal protein L37a
S100A8 S100 calcium binding protein A8
SATB1 SATB homeobox 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIRT3 sirtuin 3
SLC35F2 solute carrier family 35, member F2
SPAG4 sperm associated antigen 4
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACTG2 actin, gamma 2, smooth muscle, enteric
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
AREG amphiregulin
BTG2 BTG family, member 2
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CXCL14 chemokine (C-X-C motif) ligand 14
DLC1 DLC1 Rho GTPase activating protein
DUSP6 dual specificity phosphatase 6
EPHA2 EPH receptor A2
FABP4 fatty acid binding protein 4, adipocyte
FOSL1 FOS-like antigen 1
GPX2 glutathione peroxidase 2
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
LAMC2 laminin, gamma 2
LRP4 low density lipoprotein receptor-related protein 4
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RPA1 replication protein A1, 70kDa
S100A12 S100 calcium binding protein A12
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TRAPPC3 trafficking protein particle complex 3