BRD-K12343256_trametinib_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K12343256_trametinib_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSM3 acyl-CoA synthetase medium-chain family member 3
AHSG alpha-2-HS-glycoprotein
APOA2 apolipoprotein A-II
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
CALR calreticulin
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CERS6 ceramide synthase 6
CFB complement factor B
CLIC3 chloride intracellular channel 3
CNN3 calponin 3, acidic
COCH cochlin
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DSP desmoplakin
EREG epiregulin
FAM117A family with sequence similarity 117, member A
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLUL glutamate-ammonia ligase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
HIPK1 homeodomain interacting protein kinase 1
HOOK2 hook microtubule-tethering protein 2
HP haptoglobin
IGFBP1 insulin-like growth factor binding protein 1
IL1RN interleukin 1 receptor antagonist
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LYRM1 LYR motif containing 1
MET MET proto-oncogene, receptor tyrosine kinase
MTSS1 metastasis suppressor 1
NPR3 natriuretic peptide receptor 3
PCP4 Purkinje cell protein 4
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REPIN1 replication initiator 1
RHOA ras homolog family member A
RPS5 ribosomal protein S5
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
STK26 serine/threonine protein kinase 26
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANK2 ankyrin 2, neuronal
ASPA aspartoacylase
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CD44 CD44 molecule (Indian blood group)
CH25H cholesterol 25-hydroxylase
CHN1 chimerin 1
CKLF chemokine-like factor
COL15A1 collagen, type XV, alpha 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
ECM1 extracellular matrix protein 1
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FBP1 fructose-1,6-bisphosphatase 1
FOSL1 FOS-like antigen 1
GAS1 growth arrest-specific 1
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HOXC6 homeobox C6
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IL13RA2 interleukin 13 receptor, alpha 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGT1 magnesium transporter 1
MME membrane metallo-endopeptidase
MSLN mesothelin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA2 paraneoplastic Ma antigen 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRO protein tyrosine phosphatase, receptor type, O
RNASET2 ribonuclease T2
S100P S100 calcium binding protein P
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIM22 tripartite motif containing 22
TXNDC9 thioredoxin domain containing 9