BRD-K12343256_trametinib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

244 genes differentially expressed following the BRD-K12343256_trametinib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABHD4 abhydrolase domain containing 4
ACAA1 acetyl-CoA acyltransferase 1
ACSF2 acyl-CoA synthetase family member 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAD aminolevulinate dehydratase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANG angiogenin, ribonuclease, RNase A family, 5
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
APOA1 apolipoprotein A-I
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APOM apolipoprotein M
AUH AU RNA binding protein/enoyl-CoA hydratase
BLNK B-cell linker
BLVRB biliverdin reductase B
C1ORF115 chromosome 1 open reading frame 115
C5 complement component 5
CAT catalase
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDO1 cysteine dioxygenase type 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DAAM1 dishevelled associated activator of morphogenesis 1
DACH1 dachshund family transcription factor 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
EMX2 empty spiracles homeobox 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FAM63A family with sequence similarity 63, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
FZD5 frizzled class receptor 5
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPC3 glypican 3
GPER1 G protein-coupled estrogen receptor 1
GPM6B glycoprotein M6B
GSTA4 glutathione S-transferase alpha 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSDL2 hydroxysteroid dehydrogenase like 2
IL17RB interleukin 17 receptor B
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLHDC2 kelch domain containing 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LMO2 LIM domain only 2 (rhombotin-like 1)
LSP1 lymphocyte-specific protein 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYST lysosomal trafficking regulator
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
OPN3 opsin 3
PAH phenylalanine hydroxylase
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1 PDZ domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PEX11A peroxisomal biogenesis factor 11 alpha
PGRMC2 progesterone receptor membrane component 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAP2A RAP2A, member of RAS oncogene family
RNASE4 ribonuclease, RNase A family, 4
RXRA retinoid X receptor, alpha
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SESN1 sestrin 1
SIDT2 SID1 transmembrane family, member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SNN stannin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
YPEL5 yippee-like 5 (Drosophila)
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
BMP4 bone morphogenetic protein 4
C1QBP complement component 1, q subcomponent binding protein
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CLDND1 claudin domain containing 1
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPH2 DPH2 homolog (S. cerevisiae)
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM3C family with sequence similarity 3, member C
FAT1 FAT atypical cadherin 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GREM1 gremlin 1, DAN family BMP antagonist
GTPBP4 GTP binding protein 4
GYG1 glycogenin 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
KIAA0020 KIAA0020
KLK10 kallikrein-related peptidase 10
KRT8 keratin 8, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
MAB21L2 mab-21-like 2 (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MCL1 myeloid cell leukemia 1
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NNMT nicotinamide N-methyltransferase
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PDAP1 PDGFA associated protein 1
PDLIM3 PDZ and LIM domain 3
PFDN2 prefoldin subunit 2
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMP22 peripheral myelin protein 22
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PRMT1 protein arginine methyltransferase 1
PRNP prion protein
PUS7 pseudouridylate synthase 7 (putative)
RPP25 ribonuclease P/MRP 25kDa subunit
RRM2 ribonucleotide reductase M2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
STC1 stanniocalcin 1
STIP1 stress-induced phosphoprotein 1
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
WDR3 WD repeat domain 3
YBX3 Y box binding protein 3
YES1 YES proto-oncogene 1, Src family tyrosine kinase