BRD-K12244279_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-K12244279_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARMT1 acidic residue methyltransferase 1
ASS1 argininosuccinate synthase 1
BRD8 bromodomain containing 8
CCNG2 cyclin G2
CD99 CD99 molecule
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFNA1 ephrin-A1
ERBB3 erb-b2 receptor tyrosine kinase 3
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
HSDL2 hydroxysteroid dehydrogenase like 2
ITM2C integral membrane protein 2C
KIF20A kinesin family member 20A
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MGST3 microsomal glutathione S-transferase 3
NUSAP1 nucleolar and spindle associated protein 1
PDZK1 PDZ domain containing 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLXNB1 plexin B1
PLXNB2 plexin B2
PRR15L proline rich 15-like
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RXRA retinoid X receptor, alpha
SELENBP1 selenium binding protein 1
SESN1 sestrin 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADGRE5 adhesion G protein-coupled receptor E5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AIM2 absent in melanoma 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ATG101 autophagy related 101
AXIN1 axin 1
BOP1 block of proliferation 1
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CD3EAP CD3e molecule, epsilon associated protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHERP calcium homeostasis endoplasmic reticulum protein
CNN3 calponin 3, acidic
COCH cochlin
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKC1 dyskeratosis congenita 1, dyskerin
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPH2 DPH2 homolog (S. cerevisiae)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
E2F5 E2F transcription factor 5, p130-binding
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETV5 ets variant 5
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FKBP11 FK506 binding protein 11, 19 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GLS glutaminase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
GSPT1 G1 to S phase transition 1
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
IRF1 interferon regulatory factor 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
KIAA0020 KIAA0020
KLF10 Kruppel-like factor 10
KLK11 kallikrein-related peptidase 11
LCK LCK proto-oncogene, Src family tyrosine kinase
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LOXL1 lysyl oxidase-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAP1B microtubule-associated protein 1B
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MINA MYC induced nuclear antigen
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFE2L3 nuclear factor, erythroid 2-like 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAK1IP1 PAK1 interacting protein 1
PDCD11 programmed cell death 11
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTRH2 peptidyl-tRNA hydrolase 2
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RPP40 ribonuclease P/MRP 40kDa subunit
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SEH1L SEH1-like (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC35F2 solute carrier family 35, member F2
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCL1A T-cell leukemia/lymphoma 1A
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52 tumor protein D52
TRIB2 tribbles pseudokinase 2
TRIM27 tripartite motif containing 27
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UCK2 uridine-cytidine kinase 2
UPP1 uridine phosphorylase 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
WDR74 WD repeat domain 74
WWTR1 WW domain containing transcription regulator 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZNF593 zinc finger protein 593
ZNHIT6 zinc finger, HIT-type containing 6