BRD-K12244279_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K12244279_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BDH2 3-hydroxybutyrate dehydrogenase, type 2
C14ORF132 chromosome 14 open reading frame 132
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CD99 CD99 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLU clusterin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GPER1 G protein-coupled estrogen receptor 1
HLTF helicase-like transcription factor
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL17RB interleukin 17 receptor B
KDM5D lysine (K)-specific demethylase 5D
MUC1 mucin 1, cell surface associated
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
QPRT quinolinate phosphoribosyltransferase
RAD51C RAD51 paralog C
RXRA retinoid X receptor, alpha
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SFTPB surfactant protein B
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
TXNIP thioredoxin interacting protein
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CD200 CD200 molecule
CD9 CD9 molecule
CLDN4 claudin 4
CNN1 calponin 1, basic, smooth muscle
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EPHA2 EPH receptor A2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLRX glutaredoxin (thioltransferase)
GSN gelsolin
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA1 high mobility group AT-hook 1
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
IGL immunoglobulin lambda locus
INPP1 inositol polyphosphate-1-phosphatase
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT18 keratin 18, type I
LMCD1 LIM and cysteine-rich domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCKSL1 MARCKS-like 1
MEF2C myocyte enhancer factor 2C
PDLIM3 PDZ and LIM domain 3
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCAN1 regulator of calcineurin 1
RTN2 reticulon 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
TACSTD2 tumor-associated calcium signal transducer 2
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TOR1A torsin family 1, member A (torsin A)
TOX3 TOX high mobility group box family member 3
TRIB1 tribbles pseudokinase 1
UPP1 uridine phosphorylase 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing