BRD-K12184916_NVP-BEZ235_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF3 activating transcription factor 3
AURKA aurora kinase A
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BMP4 bone morphogenetic protein 4
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CCNF cyclin F
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPE centromere protein E, 312kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
EDN1 endothelin 1
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
FAS Fas cell surface death receptor
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM2 intercellular adhesion molecule 2
IRF6 interferon regulatory factor 6
KDM3A lysine (K)-specific demethylase 3A
KIAA0355 KIAA0355
KIF20A kinesin family member 20A
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
METTL7A methyltransferase like 7A
MYBPC1 myosin binding protein C, slow type
NEBL nebulette
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUSAP1 nucleolar and spindle associated protein 1
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSRC1 proline/serine-rich coiled-coil 1
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TSC22D3 TSC22 domain family, member 3
TTK TTK protein kinase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AIF1 allograft inflammatory factor 1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATMIN ATM interactor
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BTBD3 BTB (POZ) domain containing 3
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CES1 carboxylesterase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL15A1 collagen, type XV, alpha 1
COL6A3 collagen, type VI, alpha 3
CTSH cathepsin H
CTSZ cathepsin Z
FBN2 fibrillin 2
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
JADE2 jade family PHD finger 2
MEIS1 Meis homeobox 1
MPPED2 metallophosphoesterase domain containing 2
MXRA7 matrix-remodelling associated 7
NRP1 neuropilin 1
PHYH phytanoyl-CoA 2-hydroxylase
PRKCB protein kinase C, beta
PRMT1 protein arginine methyltransferase 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
TGFBI transforming growth factor, beta-induced, 68kDa
TNS1 tensin 1
UGDH UDP-glucose 6-dehydrogenase
XIST X inactive specific transcript (non-protein coding)