BRD-K12184916_NVP-BEZ235_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AGTR1 angiotensin II receptor, type 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPN asporin
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
CCNG2 cyclin G2
CD24 CD24 molecule
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
FBN2 fibrillin 2
FST follistatin
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTZ1 glutathione S-transferase zeta 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
KIAA0355 KIAA0355
KRT23 keratin 23, type I
LRRC15 leucine rich repeat containing 15
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
NID2 nidogen 2 (osteonidogen)
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RGS5 regulator of G-protein signaling 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSC22D3 TSC22 domain family, member 3
TYROBP TYRO protein tyrosine kinase binding protein

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ACTN1 actinin, alpha 1
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
CHI3L2 chitinase 3-like 2
CLTB clathrin, light chain B
COL1A1 collagen, type I, alpha 1
DENND2D DENN/MADD domain containing 2D
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EXOSC4 exosome component 4
FLNA filamin A, alpha
GDE1 glycerophosphodiester phosphodiesterase 1
HOXC6 homeobox C6
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP5 insulin-like growth factor binding protein 5
LAMP1 lysosomal-associated membrane protein 1
MAL mal, T-cell differentiation protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
PRAME preferentially expressed antigen in melanoma
PRDX2 peroxiredoxin 2
PTPRM protein tyrosine phosphatase, receptor type, M
QPCT glutaminyl-peptide cyclotransferase
RRP1B ribosomal RNA processing 1B
TGFBI transforming growth factor, beta-induced, 68kDa
TRIB2 tribbles pseudokinase 2