BRD-K12184916_NVP-BEZ235_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKAP13 A kinase (PRKA) anchor protein 13
ALAS2 5'-aminolevulinate synthase 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD36B ankyrin repeat domain 36B
ATXN1 ataxin 1
BACE2 beta-site APP-cleaving enzyme 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBR3 carbonyl reductase 3
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK7 cyclin-dependent kinase 7
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CLDN3 claudin 3
CLDN4 claudin 4
COBL cordon-bleu WH2 repeat protein
CREBL2 cAMP responsive element binding protein-like 2
CST1 cystatin SN
CTSL cathepsin L
CYTH1 cytohesin 1
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
FAS Fas cell surface death receptor
FAXDC2 fatty acid hydroxylase domain containing 2
FBXO11 F-box protein 11
FGF13 fibroblast growth factor 13
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FST follistatin
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GYPC glycophorin C (Gerbich blood group)
HECA headcase homolog (Drosophila)
HIST1H2AC histone cluster 1, H2ac
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IL6ST interleukin 6 signal transducer
IQGAP1 IQ motif containing GTPase activating protein 1
JARID2 jumonji, AT rich interactive domain 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MLPH melanophilin
MTSS1 metastasis suppressor 1
MVP major vault protein
MYLIP myosin regulatory light chain interacting protein
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NT5E 5'-nucleotidase, ecto (CD73)
PDCD6 programmed cell death 6
PGAP3 post-GPI attachment to proteins 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PRSS8 protease, serine, 8
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RPL36 ribosomal protein L36
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAMP1 secretory carrier membrane protein 1
SELENBP1 selenium binding protein 1
SFRP1 secreted frizzled-related protein 1
SPDEF SAM pointed domain containing ETS transcription factor
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STXBP2 syntaxin binding protein 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM87A transmembrane protein 87A
TSPAN5 tetraspanin 5
TXNIP thioredoxin interacting protein
WASL Wiskott-Aldrich syndrome-like
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNK1 WNK lysine deficient protein kinase 1
ZBTB38 zinc finger and BTB domain containing 38
ZNF217 zinc finger protein 217
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACLY ATP citrate lyase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALG8 ALG8, alpha-1,3-glucosyltransferase
AQP1 aquaporin 1 (Colton blood group)
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CHEK2 checkpoint kinase 2
CLU clusterin
CTPS1 CTP synthase 1
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
DHCR7 7-dehydrocholesterol reductase
DNM1L dynamin 1-like
EBP emopamil binding protein (sterol isomerase)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GJA1 gap junction protein, alpha 1, 43kDa
GPC3 glypican 3
GSTM3 glutathione S-transferase mu 3 (brain)
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LAT2 linker for activation of T cells family, member 2
LIMCH1 LIM and calponin homology domains 1
LUM lumican
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NME1 NME/NM23 nucleoside diphosphate kinase 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PCCB propionyl CoA carboxylase, beta polypeptide
PHGDH phosphoglycerate dehydrogenase
PNP purine nucleoside phosphorylase
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PYCR1 pyrroline-5-carboxylate reductase 1
QDPR quinoid dihydropteridine reductase
RBBP8 retinoblastoma binding protein 8
S100A2 S100 calcium binding protein A2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
ST7 suppression of tumorigenicity 7
SULF1 sulfatase 1
TCL1A T-cell leukemia/lymphoma 1A
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TPX2 TPX2, microtubule-associated
UBE2A ubiquitin-conjugating enzyme E2A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMIZ1 zinc finger, MIZ-type containing 1