BRD-K12184916_NVP-BEZ235_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMOTL2 angiomotin like 2
ANXA3 annexin A3
ANXA4 annexin A4
ATP9A ATPase, class II, type 9A
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD81 CD81 molecule
CD99 CD99 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CLIC5 chloride intracellular channel 5
CTGF connective tissue growth factor
CTSA cathepsin A
CTSD cathepsin D
CTSF cathepsin F
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DALRD3 DALR anticodon binding domain containing 3
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EIF3F eukaryotic translation initiation factor 3, subunit F
EMX2 empty spiracles homeobox 2
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ETHE1 ethylmalonic encephalopathy 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
GAB2 GRB2-associated binding protein 2
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
HBP1 HMG-box transcription factor 1
HEBP2 heme binding protein 2
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LGALS4 lectin, galactoside-binding, soluble, 4
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MFAP5 microfibrillar associated protein 5
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MVP major vault protein
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
NPDC1 neural proliferation, differentiation and control, 1
NPEPL1 aminopeptidase-like 1
NPR1 natriuretic peptide receptor 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCM1 pericentriolar material 1
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PERP PERP, TP53 apoptosis effector
PGLS 6-phosphogluconolactonase
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
PTX3 pentraxin 3, long
PYCARD PYD and CARD domain containing
RBKS ribokinase
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIRT3 sirtuin 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC38A2 solute carrier family 38, member 2
SPINK4 serine peptidase inhibitor, Kazal type 4
SPP1 secreted phosphoprotein 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
SRSF6 serine/arginine-rich splicing factor 6
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
VAT1 vesicle amine transport 1
WBP5 WW domain binding protein 5
WDR45 WD repeat domain 45

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATAD2 ATPase family, AAA domain containing 2
BARD1 BRCA1 associated RING domain 1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALML3 calmodulin-like 3
CBX5 chromobox homolog 5
CCNE2 cyclin E2
CCNF cyclin F
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK2 cyclin-dependent kinase 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CRLF1 cytokine receptor-like factor 1
CSRP2 cysteine and glycine-rich protein 2
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FGL2 fibrinogen-like 2
FKBP14 FK506 binding protein 14, 22 kDa
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HK2 hexokinase 2
HSPA14 heat shock 70kDa protein 14
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
KIF18B kinesin family member 18B
LMNB1 lamin B1
LMNB2 lamin B2
LRP4 low density lipoprotein receptor-related protein 4
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MICB MHC class I polypeptide-related sequence B
MINA MYC induced nuclear antigen
MYCBP MYC binding protein
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKD3 protein kinase D3
PRR15L proline rich 15-like
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SESN1 sestrin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMC2 structural maintenance of chromosomes 2
SPAG4 sperm associated antigen 4
SPC25 SPC25, NDC80 kinetochore complex component
STRA13 stimulated by retinoic acid 13
TIMELESS timeless circadian clock
TMPO thymopoietin
TNC tenascin C
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VRK1 vaccinia related kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein