BRD-K12184916_NVP-BEZ235_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
ANOS1 anosmin 1
ANXA1 annexin A1
ANXA4 annexin A4
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
EPCAM epithelial cell adhesion molecule
F11R F11 receptor
FAM107A family with sequence similarity 107, member A
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRN granulin
HBP1 HMG-box transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMG20B high mobility group 20B
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
MACF1 microtubule-actin crosslinking factor 1
MAGEA12 melanoma antigen family A12
MUC16 mucin 16, cell surface associated
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB31 RAB31, member RAS oncogene family
RGS10 regulator of G-protein signaling 10
SFRP4 secreted frizzled-related protein 4
SLC38A1 solute carrier family 38, member 1
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
TCTA T-cell leukemia translocation altered
TMEM30B transmembrane protein 30B
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AQP3 aquaporin 3 (Gill blood group)
BARD1 BRCA1 associated RING domain 1
CCND2 cyclin D2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPU centromere protein U
CTPS1 CTP synthase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
ICMT isoprenylcysteine carboxyl methyltransferase
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SCML1 sex comb on midleg-like 1 (Drosophila)
SHCBP1 SHC SH2-domain binding protein 1