BRD-K12184916_NVP-BEZ235_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ANXA1 annexin A1
ANXA4 annexin A4
BHLHE41 basic helix-loop-helix family, member e41
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CGA glycoprotein hormones, alpha polypeptide
COL18A1 collagen, type XVIII, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTSA cathepsin A
CTSH cathepsin H
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
EIF5A eukaryotic translation initiation factor 5A
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNPDA1 glucosamine-6-phosphate deaminase 1
GPX4 glutathione peroxidase 4
GRN granulin
ICAM1 intercellular adhesion molecule 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2R insulin-like growth factor 2 receptor
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MGLL monoglyceride lipase
MLPH melanophilin
MMP1 matrix metallopeptidase 1
NEU1 sialidase 1 (lysosomal sialidase)
ORAI3 ORAI calcium release-activated calcium modulator 3
OXTR oxytocin receptor
PDGFC platelet derived growth factor C
PROS1 protein S (alpha)
PRSS8 protease, serine, 8
RAP1GAP RAP1 GTPase activating protein
S100P S100 calcium binding protein P
SLC16A4 solute carrier family 16, member 4
SLC16A6 solute carrier family 16, member 6
SLC22A18 solute carrier family 22, member 18
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQSTM1 sequestosome 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND2 cyclin D2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CENPU centromere protein U
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NELL2 NEL-like 2 (chicken)
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
RANBP1 RAN binding protein 1
REEP1 receptor accessory protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCML1 sex comb on midleg-like 1 (Drosophila)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SUB1 SUB1 homolog (S. cerevisiae)
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TUBG1 tubulin, gamma 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein