BRD-K12184916_NVP-BEZ235_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C8ORF4 chromosome 8 open reading frame 4
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPE centromere protein E, 312kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYTH1 cytohesin 1
DST dystonin
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMOX1 heme oxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IL15 interleukin 15
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LPL lipoprotein lipase
MME membrane metallo-endopeptidase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PTK2 protein tyrosine kinase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
SKAP2 src kinase associated phosphoprotein 2
SLC35F2 solute carrier family 35, member F2
SOX4 SRY (sex determining region Y)-box 4
STOM stomatin
STX1A syntaxin 1A (brain)
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
BAG2 BCL2-associated athanogene 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CCND1 cyclin D1
CD83 CD83 molecule
CDC25A cell division cycle 25A
DHRS2 dehydrogenase/reductase (SDR family) member 2
EMX2 empty spiracles homeobox 2
EREG epiregulin
EXOSC4 exosome component 4
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
IL1B interleukin 1, beta
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KRT18 keratin 18, type I
LOC100505650 uncharacterized LOC100505650
LPXN leupaxin
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAT2A methionine adenosyltransferase II, alpha
MEIS1 Meis homeobox 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MXRA7 matrix-remodelling associated 7
NAV3 neuron navigator 3
NUP62 nucleoporin 62kDa
PEG3 paternally expressed 3
PODXL podocalyxin-like
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
RAD51C RAD51 paralog C
RGS4 regulator of G-protein signaling 4
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SQLE squalene epoxidase
SUB1 SUB1 homolog (S. cerevisiae)
TLR4 toll-like receptor 4