BRD-K12184916_NVP-BEZ235_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP9A ATPase, class II, type 9A
BACE2 beta-site APP-cleaving enzyme 2
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
C1ORF106 chromosome 1 open reading frame 106
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CIRBP cold inducible RNA binding protein
CLIC5 chloride intracellular channel 5
COL9A2 collagen, type IX, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSH cathepsin H
CXCR4 chemokine (C-X-C motif) receptor 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DES desmin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOCK9 dedicator of cytokinesis 9
DOK5 docking protein 5
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EIF4A2 eukaryotic translation initiation factor 4A2
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM50A family with sequence similarity 50, member A
FBLN1 fibulin 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FXYD3 FXYD domain containing ion transport regulator 3
GAS6 growth arrest-specific 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GSN gelsolin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST3H2A histone cluster 3, H2a
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB4 integrin, beta 4
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LEPR leptin receptor
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MGP matrix Gla protein
MLPH melanophilin
MSLN mesothelin
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYOF myoferlin
NDRG1 N-myc downstream regulated 1
NMRK1 nicotinamide riboside kinase 1
NPDC1 neural proliferation, differentiation and control, 1
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PFKP phosphofructokinase, platelet
PHYH phytanoyl-CoA 2-hydroxylase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK2 polo-like kinase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRK protein tyrosine phosphatase, receptor type, K
QARS glutaminyl-tRNA synthetase
RAB4A RAB4A, member RAS oncogene family
RAI2 retinoic acid induced 2
RAP1GAP RAP1 GTPase activating protein
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSRP1 arginine/serine-rich protein 1
SAMD4A sterile alpha motif domain containing 4A
SCAMP1 secretory carrier membrane protein 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFTPC surfactant protein C
SH3YL1 SH3 and SYLF domain containing 1
SLC22A18 solute carrier family 22, member 18
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
SSR4 signal sequence receptor, delta
STXBP1 syntaxin binding protein 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TACC2 transforming, acidic coiled-coil containing protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
THBS3 thrombospondin 3
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TRAPPC6A trafficking protein particle complex 6A
TRIB2 tribbles pseudokinase 2
TSC22D1 TSC22 domain family, member 1
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
TWIST1 twist family bHLH transcription factor 1
USP34 ubiquitin specific peptidase 34
VAMP8 vesicle-associated membrane protein 8
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WWTR1 WW domain containing transcription regulator 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
C20ORF24 chromosome 20 open reading frame 24
CBX1 chromobox homolog 1
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
LMNB2 lamin B2
LTF lactotransferrin
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEK2 NIMA-related kinase 2
NTS neurotensin
NUP98 nucleoporin 98kDa
OIP5 Opa interacting protein 5
PHGDH phosphoglycerate dehydrogenase
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RAD23B RAD23 homolog B (S. cerevisiae)
RFC3 replication factor C (activator 1) 3, 38kDa
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELL selectin L
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORD sorbitol dehydrogenase
SRM spermidine synthase
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZDHHC6 zinc finger, DHHC-type containing 6