BRD-K12184916_NVP-BEZ235_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCK3 aarF domain containing kinase 3
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD36B ankyrin repeat domain 36B
ATF3 activating transcription factor 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNF cyclin F
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CXCL8 chemokine (C-X-C motif) ligand 8
DLX2 distal-less homeobox 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GLDC glycine dehydrogenase (decarboxylating)
GOLGA8A golgin A8 family, member A
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGF1R insulin-like growth factor 1 receptor
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PEG3 paternally expressed 3
PTGIS prostaglandin I2 (prostacyclin) synthase
RPS11 ribosomal protein S11
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFRP4 secreted frizzled-related protein 4
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
STX1A syntaxin 1A (brain)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TRIB1 tribbles pseudokinase 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BCHE butyrylcholinesterase
CCL2 chemokine (C-C motif) ligand 2
CCND3 cyclin D3
CD24 CD24 molecule
CDC25A cell division cycle 25A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSH cathepsin H
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP6 fatty acid binding protein 6, ileal
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1A heat shock 70kDa protein 1A
IFITM3 interferon induced transmembrane protein 3
IL32 interleukin 32
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MEIS3P1 Meis homeobox 3 pseudogene 1
MSRB2 methionine sulfoxide reductase B2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
PAIP1 poly(A) binding protein interacting protein 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCP4 Purkinje cell protein 4
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC62 SEC62 homolog (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOX11 SRY (sex determining region Y)-box 11
TACSTD2 tumor-associated calcium signal transducer 2
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10