BRD-K12184916_NVP-BEZ235_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

227 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C2 aldo-keto reductase family 1, member C2
ANXA1 annexin A1
APOD apolipoprotein D
ASPH aspartate beta-hydroxylase
ATF4 activating transcription factor 4
AXL AXL receptor tyrosine kinase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
C1ORF115 chromosome 1 open reading frame 115
C1RL complement component 1, r subcomponent-like
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CFB complement factor B
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF3D eukaryotic translation initiation factor 3, subunit D
ENO2 enolase 2 (gamma, neuronal)
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM107A family with sequence similarity 107, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FMO3 flavin containing monooxygenase 3
FST follistatin
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
H1F0 H1 histone family, member 0
HIST1H2AC histone cluster 1, H2ac
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP1 insulin-like growth factor binding protein 1
INPP1 inositol polyphosphate-1-phosphatase
IRS2 insulin receptor substrate 2
JOSD1 Josephin domain containing 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
LCN2 lipocalin 2
LEPR leptin receptor
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LTBP3 latent transforming growth factor beta binding protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MBNL1 muscleblind-like splicing regulator 1
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
N4BP2L2 NEDD4 binding protein 2-like 2
NPDC1 neural proliferation, differentiation and control, 1
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAM peptidylglycine alpha-amidating monooxygenase
PDLIM5 PDZ and LIM domain 5
PELI2 pellino E3 ubiquitin protein ligase family member 2
PILRB paired immunoglobin-like type 2 receptor beta
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPAP2B phosphatidic acid phosphatase type 2B
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC3 serine incorporator 3
SLC38A2 solute carrier family 38, member 2
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM140 transmembrane protein 140
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TNS3 tensin 3
TSC22D1 TSC22 domain family, member 1
TUG1 taurine up-regulated 1 (non-protein coding)
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CETN2 centrin, EF-hand protein, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC3 chloride intracellular channel 3
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CTSV cathepsin V
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HSPA14 heat shock 70kDa protein 14
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MKI67 marker of proliferation Ki-67
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG2 non-SMC condensin II complex, subunit G2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RACGAP1 Rac GTPase activating protein 1
RAD23B RAD23 homolog B (S. cerevisiae)
RFC3 replication factor C (activator 1) 3, 38kDa
RNASEH2A ribonuclease H2, subunit A
RPA1 replication protein A1, 70kDa
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN transgelin
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein