BRD-K12184916_NVP-BEZ235_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD2 abhydrolase domain containing 2
ABHD6 abhydrolase domain containing 6
ADGRF5 adhesion G protein-coupled receptor F5
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP9A ATPase, class II, type 9A
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOXN3 forkhead box N3
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GPR137B G protein-coupled receptor 137B
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H2AC histone cluster 1, H2ac
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100272216 uncharacterized LOC100272216
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL1 muscleblind-like splicing regulator 1
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MGLL monoglyceride lipase
MVP major vault protein
N4BP2L2 NEDD4 binding protein 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OXTR oxytocin receptor
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLCB4 phospholipase C, beta 4
SDPR serum deprivation response
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SPATA20 spermatogenesis associated 20
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYNGR3 synaptogyrin 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TRIB1 tribbles pseudokinase 1
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AK4 adenylate kinase 4
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND2 cyclin D2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CETN2 centrin, EF-hand protein, 2
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
E2F8 E2F transcription factor 8
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FOXM1 forkhead box M1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LMNB1 lamin B1
LMO4 LIM domain only 4
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEK2 NIMA-related kinase 2
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
P3H2 prolyl 3-hydroxylase 2
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PEA15 phosphoprotein enriched in astrocytes 15
PHGDH phosphoglycerate dehydrogenase
PKP1 plakophilin 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLPI secretory leukocyte peptidase inhibitor
SMAD1 SMAD family member 1
SPC25 SPC25, NDC80 kinetochore complex component
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein