BRD-K12184916_NVP-BEZ235_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

237 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
ARMCX1 armadillo repeat containing, X-linked 1
ATF4 activating transcription factor 4
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BAG1 BCL2-associated athanogene
BEX4 brain expressed, X-linked 4
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAST calpastatin
CCNG2 cyclin G2
CD52 CD52 molecule
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CSNK2A2 casein kinase 2, alpha prime polypeptide
CST1 cystatin SN
CTSA cathepsin A
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPP4 dipeptidyl-peptidase 4
EIF4B eukaryotic translation initiation factor 4B
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EVI2A ecotropic viral integration site 2A
FAM134A family with sequence similarity 134, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GLUL glutamate-ammonia ligase
GNPDA1 glucosamine-6-phosphate deaminase 1
GNS glucosamine (N-acetyl)-6-sulfatase
GOLGA8H golgin A8 family, member H
GPR137B G protein-coupled receptor 137B
GPX4 glutathione peroxidase 4
GRN granulin
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HEXA hexosaminidase A (alpha polypeptide)
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIZ kizuna centrosomal protein
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC399491
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MGLL monoglyceride lipase
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP6 poly (ADP-ribose) polymerase family, member 6
PDGFC platelet derived growth factor C
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RBKS ribokinase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RRAGC Ras-related GTP binding C
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A6 solute carrier family 16, member 6
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TRAM1 translocation associated membrane protein 1
TSC22D3 TSC22 domain family, member 3
UBXN1 UBX domain protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WWOX WW domain containing oxidoreductase
YBX3 Y box binding protein 3
ZDHHC7 zinc finger, DHHC-type containing 7
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALG8 ALG8, alpha-1,3-glucosyltransferase
ARL4C ADP-ribosylation factor-like 4C
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
ENAH enabled homolog (Drosophila)
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO21 F-box protein 21
FEN1 flap structure-specific endonuclease 1
FGFR4 fibroblast growth factor receptor 4
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICMT isoprenylcysteine carboxyl methyltransferase
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
ITM2A integral membrane protein 2A
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAK16 MAK16 homolog (S. cerevisiae)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCAPD3 non-SMC condensin II complex, subunit D3
NES nestin
NLRP2 NLR family, pyrin domain containing 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRMT1 protein arginine methyltransferase 1
PSPH phosphoserine phosphatase
RCAN1 regulator of calcineurin 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPTSSA serine palmitoyltransferase, small subunit A
SRM spermidine synthase
STK10 serine/threonine kinase 10
TBC1D4 TBC1 domain family, member 4
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TMPO thymopoietin
TRAC T cell receptor alpha constant
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein