BRD-K12184916_NVP-BEZ235_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
AKAP13 A kinase (PRKA) anchor protein 13
ANKRD36B ankyrin repeat domain 36B
ARMCX1 armadillo repeat containing, X-linked 1
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CAMLG calcium modulating ligand
CCNG2 cyclin G2
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC3 chloride intracellular channel 3
COBL cordon-bleu WH2 repeat protein
COL11A1 collagen, type XI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSB cathepsin B
DEPTOR DEP domain containing MTOR-interacting protein
DMXL1 Dmx-like 1
EIF4B eukaryotic translation initiation factor 4B
FAM63A family with sequence similarity 63, member A
FXR1 fragile X mental retardation, autosomal homolog 1
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
GRN granulin
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
ISG20 interferon stimulated exonuclease gene 20kDa
KIZ kizuna centrosomal protein
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMB2 laminin, beta 2 (laminin S)
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LINC00342 long intergenic non-protein coding RNA 342
LTBP2 latent transforming growth factor beta binding protein 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP2K5 mitogen-activated protein kinase kinase 5
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MME membrane metallo-endopeptidase
MYOF myoferlin
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L1 nuclear factor, erythroid 2-like 1
NID2 nidogen 2 (osteonidogen)
ORAI3 ORAI calcium release-activated calcium modulator 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLXND1 plexin D1
PNRC1 proline-rich nuclear receptor coactivator 1
PSAP prosaposin
R3HDM2 R3H domain containing 2
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
RGS10 regulator of G-protein signaling 10
RHOF ras homolog family member F (in filopodia)
RPL38 ribosomal protein L38
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC16A6 solute carrier family 16, member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATA20 spermatogenesis associated 20
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SQRDL sulfide quinone reductase-like (yeast)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCTA T-cell leukemia translocation altered
THBS3 thrombospondin 3
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TSC22D3 TSC22 domain family, member 3
TYMP thymidine phosphorylase
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATAD2 ATPase family, AAA domain containing 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CP ceruloplasmin (ferroxidase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DLD dihydrolipoamide dehydrogenase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNAS GNAS complex locus
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
ITM2A integral membrane protein 2A
KIAA0485 uncharacterized LOC57235
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIMCH1 LIM and calponin homology domains 1
LMNB1 lamin B1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCAPH non-SMC condensin I complex, subunit H
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
POLD2 polymerase (DNA directed), delta 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS2 regulator of G-protein signaling 2
S100A2 S100 calcium binding protein A2
SHCBP1 SHC SH2-domain binding protein 1
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TMEM45A transmembrane protein 45A
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TNC tenascin C
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VRK1 vaccinia related kinase 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein