BRD-K12184916_NVP-BEZ235_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKAP1 A kinase (PRKA) anchor protein 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ATP9A ATPase, class II, type 9A
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCL5 chemokine (C-C motif) ligand 5
CD44 CD44 molecule (Indian blood group)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEP57 centrosomal protein 57kDa
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISP3 cysteine-rich secretory protein 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP6 dual specificity phosphatase 6
EIF4B eukaryotic translation initiation factor 4B
EPAS1 endothelial PAS domain protein 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNLY granulysin
GPR137B G protein-coupled receptor 137B
GPX4 glutathione peroxidase 4
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC399491
MFSD10 major facilitator superfamily domain containing 10
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MPDZ multiple PDZ domain protein
NKG7 natural killer cell granule protein 7
NONO non-POU domain containing, octamer-binding
NPDC1 neural proliferation, differentiation and control, 1
OSBPL1A oxysterol binding protein-like 1A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PGLS 6-phosphogluconolactonase
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGIF1 TGFB-induced factor homeobox 1
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDOA aldolase A, fructose-bisphosphate
AMD1 adenosylmethionine decarboxylase 1
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARF4 ADP-ribosylation factor 4
ARG2 arginase 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1ORF116 chromosome 1 open reading frame 116
CALU calumenin
CCL2 chemokine (C-C motif) ligand 2
CCNB1 cyclin B1
CD38 CD38 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A1 collagen, type I, alpha 1
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EAF2 ELL associated factor 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGF epidermal growth factor
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM98A family with sequence similarity 98, member A
FKBP14 FK506 binding protein 14, 22 kDa
FMO1 flavin containing monooxygenase 1
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT57 intraflagellar transport 57
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT14 keratin 14, type I
LAMP3 lysosomal-associated membrane protein 3
LEF1 lymphoid enhancer-binding factor 1
LRRC59 leucine rich repeat containing 59
MAGED1 melanoma antigen family D1
MALL mal, T-cell differentiation protein-like
MAN1A1 mannosidase, alpha, class 1A, member 1
MBNL1 muscleblind-like splicing regulator 1
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEFL neurofilament, light polypeptide
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PELI1 pellino E3 ubiquitin protein ligase 1
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
RSU1 Ras suppressor protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SEC24D SEC24 family member D
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORD sorbitol dehydrogenase
SPRR1A small proline-rich protein 1A
SQLE squalene epoxidase
STK17B serine/threonine kinase 17b
SUB1 SUB1 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TFF1 trefoil factor 1
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMED9 transmembrane emp24 protein transport domain containing 9
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN13 tetraspanin 13
TSPYL1 TSPY-like 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCP valosin containing protein
VSNL1 visinin-like 1
XBP1 X-box binding protein 1