BRD-K12184916_NVP-BEZ235_BT20_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

33 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_BT20_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALCAM activated leukocyte cell adhesion molecule
ARID4B AT rich interactive domain 4B (RBP1-like)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CTGF connective tissue growth factor
ERBB3 erb-b2 receptor tyrosine kinase 3
GATA3 GATA binding protein 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
MMP14 matrix metallopeptidase 14 (membrane-inserted)
OXTR oxytocin receptor
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
RGS1 regulator of G-protein signaling 1
SESN1 sestrin 1
TUBA1A tubulin, alpha 1a
TXNL4B thioredoxin-like 4B

decreased expression

Symbol Name
CDC25A cell division cycle 25A
CDKN2A cyclin-dependent kinase inhibitor 2A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
G0S2 G0/G1 switch 2
GPX3 glutathione peroxidase 3
IGF1 insulin-like growth factor 1 (somatomedin C)
LGALS3 lectin, galactoside-binding, soluble, 3
MAT2A methionine adenosyltransferase II, alpha
PAK1IP1 PAK1 interacting protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RHOBTB3 Rho-related BTB domain containing 3
SCG5 secretogranin V
TMEM176B transmembrane protein 176B
TUBA4A tubulin, alpha 4a