BRD-K12184916_NVP-BEZ235_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

190 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
BACE2 beta-site APP-cleaving enzyme 2
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF62 chromosome 6 open reading frame 62
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL4A5 collagen, type IV, alpha 5
CREBL2 cAMP responsive element binding protein-like 2
CTGF connective tissue growth factor
DST dystonin
ELANE elastase, neutrophil expressed
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HEXB hexosaminidase B (beta polypeptide)
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ILK integrin-linked kinase
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KDM4B lysine (K)-specific demethylase 4B
KIAA1033 KIAA1033
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPDC1 neural proliferation, differentiation and control, 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDE4B phosphodiesterase 4B, cAMP-specific
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PTTG1IP pituitary tumor-transforming 1 interacting protein
RAB17 RAB17, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RBM47 RNA binding motif protein 47
RBPMS RNA binding protein with multiple splicing
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SOD2 superoxide dismutase 2, mitochondrial
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STON1 stonin 1
STX7 syntaxin 7
STXBP2 syntaxin binding protein 2
SYNJ2 synaptojanin 2
TACC1 transforming, acidic coiled-coil containing protein 1
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPP1 tripeptidyl peptidase I
TRPS1 trichorhinophalangeal syndrome I
UBE2B ubiquitin-conjugating enzyme E2B
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADORA2B adenosine A2b receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX15B arachidonate 15-lipoxygenase, type B
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATPIF1 ATPase inhibitory factor 1
CA2 carbonic anhydrase II
CALML4 calmodulin-like 4
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CSTA cystatin A (stefin A)
CXCL11 chemokine (C-X-C motif) ligand 11
CYB561 cytochrome b561
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
FEN1 flap structure-specific endonuclease 1
GLS glutaminase
HACD3 3-hydroxyacyl-CoA dehydratase 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ILF2 interleukin enhancer binding factor 2
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MALL mal, T-cell differentiation protein-like
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MORC4 MORC family CW-type zinc finger 4
MRPL12 mitochondrial ribosomal protein L12
MRPS16 mitochondrial ribosomal protein S16
NELL2 NEL-like 2 (chicken)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPR3 natriuretic peptide receptor 3
P4HB prolyl 4-hydroxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSAT1 phosphoserine aminotransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
STAT1 signal transducer and activator of transcription 1, 91kDa
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM109 transmembrane protein 109
TMPO thymopoietin
TP53 tumor protein p53
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
XK X-linked Kx blood group
ZWINT ZW10 interacting kinetochore protein