BRD-K12184916_NVP-BEZ235_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMDHD2 amidohydrolase domain containing 2
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BCL2A1 BCL2-related protein A1
C14ORF159 chromosome 14 open reading frame 159
C6ORF48 chromosome 6 open reading frame 48
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CNN1 calponin 1, basic, smooth muscle
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSK cathepsin K
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DPH5 diphthamide biosynthesis 5
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
EPS8 epidermal growth factor receptor pathway substrate 8
FXR1 fragile X mental retardation, autosomal homolog 1
GATAD1 GATA zinc finger domain containing 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GSDMB gasdermin B
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-E major histocompatibility complex, class I, E
HOPX HOP homeobox
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO7 importin 7
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LRPPRC leucine-rich pentatricopeptide repeat containing
LTA4H leukotriene A4 hydrolase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MNT MAX network transcriptional repressor
MTA1 metastasis associated 1
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
MYH11 myosin, heavy chain 11, smooth muscle
MYO5C myosin VC
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NONO non-POU domain containing, octamer-binding
NOTCH1 notch 1
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PEG3 paternally expressed 3
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
QARS glutaminyl-tRNA synthetase
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RPL22 ribosomal protein L22
RPL28 ribosomal protein L28
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RPS9 ribosomal protein S9
RSL1D1 ribosomal L1 domain containing 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A6 solute carrier family 16, member 6
SQSTM1 sequestosome 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TPM2 tropomyosin 2 (beta)
TRAF5 TNF receptor-associated factor 5
TSPAN4 tetraspanin 4
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WFDC1 WAP four-disulfide core domain 1
ZNF277 zinc finger protein 277
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDOC aldolase C, fructose-bisphosphate
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCND3 cyclin D3
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CIT citron rho-interacting serine/threonine kinase
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
CTSC cathepsin C
CTSG cathepsin G
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
FSTL1 follistatin-like 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GSTA1 glutathione S-transferase alpha 1
H2AFX H2A histone family, member X
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NES nestin
PARP2 poly (ADP-ribose) polymerase 2
PDZK1 PDZ domain containing 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRDX2 peroxiredoxin 2
RAD51C RAD51 paralog C
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SC5D sterol-C5-desaturase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SRGN serglycin
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TK1 thymidine kinase 1, soluble
TSPAN13 tetraspanin 13
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)