BRD-K12184916_-666_SW620_6.0_h_0.63_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K12184916_-666_SW620_6.0_h_0.63_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AIDA axin interactor, dorsalization associated
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
BPTF bromodomain PHD finger transcription factor
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CFD complement factor D (adipsin)
CLEC2B C-type lectin domain family 2, member B
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DST dystonin
EGFR epidermal growth factor receptor
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF5 eukaryotic translation initiation factor 5
EMP2 epithelial membrane protein 2
EPAS1 endothelial PAS domain protein 1
ERAP1 endoplasmic reticulum aminopeptidase 1
F11R F11 receptor
FAM129A family with sequence similarity 129, member A
FST follistatin
GRB7 growth factor receptor-bound protein 7
GSE1 Gse1 coiled-coil protein
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUP junction plakoglobin
KLHDC2 kelch domain containing 2
LAMB3 laminin, beta 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MKNK1 MAP kinase interacting serine/threonine kinase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDRG1 N-myc downstream regulated 1
PDGFD platelet derived growth factor D
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLXNA1 plexin A1
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PPOX protoporphyrinogen oxidase
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRO protein tyrosine phosphatase, receptor type, O
RAD51AP1 RAD51 associated protein 1
RB1CC1 RB1-inducible coiled-coil 1
RBM34 RNA binding motif protein 34
RECQL RecQ helicase-like
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SDC4 syndecan 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFTPA2 surfactant protein A2
SPINK1 serine peptidase inhibitor, Kazal type 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAGLN2 transgelin 2
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TNS3 tensin 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UPP1 uridine phosphorylase 1
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF277 zinc finger protein 277
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACLY ATP citrate lyase
ADCY9 adenylate cyclase 9
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ASRGL1 asparaginase like 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIN1 bridging integrator 1
BST2 bone marrow stromal cell antigen 2
C14ORF2 chromosome 14 open reading frame 2
CALU calumenin
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC11A C-type lectin domain family 11, member A
CRYAB crystallin, alpha B
CTPS1 CTP synthase 1
CTSG cathepsin G
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECI2 enoyl-CoA delta isomerase 2
ENDOG endonuclease G
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FAM216A family with sequence similarity 216, member A
FOLR1 folate receptor 1 (adult)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCLM glutamate-cysteine ligase, modifier subunit
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HHEX hematopoietically expressed homeobox
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IRF8 interferon regulatory factor 8
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JMJD6 jumonji domain containing 6
KAZN kazrin, periplakin interacting protein
KRT10 keratin 10, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LIPG lipase, endothelial
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLEC malectin
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYCBP MYC binding protein
NAAA N-acylethanolamine acid amidase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP98 nucleoporin 98kDa
PDZK1 PDZ domain containing 1
PENK proenkephalin
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PIR pirin (iron-binding nuclear protein)
PLK2 polo-like kinase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PROM1 prominin 1
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PTDSS1 phosphatidylserine synthase 1
RBP1 retinol binding protein 1, cellular
RGS4 regulator of G-protein signaling 4
SAC3D1 SAC3 domain containing 1
SACS sacsin molecular chaperone
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SPATS2L spermatogenesis associated, serine-rich 2-like
TAGLN transgelin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM109 transmembrane protein 109
TMEM47 transmembrane protein 47
TPPP3 tubulin polymerization-promoting protein family member 3
TUBG1 tubulin, gamma 1
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1