BRD-K12184916_-666_HA1E_6.0_h_0.63_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K12184916_-666_HA1E_6.0_h_0.63_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADGRL4 adhesion G protein-coupled receptor L4
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BGN biglycan
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CAV2 caveolin 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CYTH1 cytohesin 1
DUSP6 dual specificity phosphatase 6
EAPP E2F-associated phosphoprotein
EDN1 endothelin 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FN1 fibronectin 1
FOXN3 forkhead box N3
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GATAD1 GATA zinc finger domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
H3F3B H3 histone, family 3B (H3.3B)
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
IGF1R insulin-like growth factor 1 receptor
INHBA inhibin, beta A
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KIAA0355 KIAA0355
KLF11 Kruppel-like factor 11
KLF6 Kruppel-like factor 6
KLHDC2 kelch domain containing 2
KLHL21 kelch-like family member 21
KRT18 keratin 18, type I
LITAF lipopolysaccharide-induced TNF factor
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L1 NEDD4 binding protein 2-like 1
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
NUAK1 NUAK family, SNF1-like kinase, 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PTPRK protein tyrosine phosphatase, receptor type, K
RIOK3 RIO kinase 3
SAMD4A sterile alpha motif domain containing 4A
SFRP1 secreted frizzled-related protein 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AMACR alpha-methylacyl-CoA racemase
AMD1 adenosylmethionine decarboxylase 1
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
AURKA aurora kinase A
BST2 bone marrow stromal cell antigen 2
CALML3 calmodulin-like 3
CDC25A cell division cycle 25A
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FBLN1 fibulin 1
HAT1 histone acetyltransferase 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA14 heat shock 70kDa protein 14
HSPB8 heat shock 22kDa protein 8
INTS6 integrator complex subunit 6
KIF5B kinesin family member 5B
MEIS2 Meis homeobox 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NUP98 nucleoporin 98kDa
OAT ornithine aminotransferase
PI3 peptidase inhibitor 3, skin-derived
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGDS prostaglandin D2 synthase 21kDa (brain)
QDPR quinoid dihydropteridine reductase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMHD1 SAM domain and HD domain 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
TARS threonyl-tRNA synthetase
TBX3 T-box 3
TSPAN13 tetraspanin 13