BRD-K12079898_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

27 genes differentially expressed following the BRD-K12079898_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN1 actinin, alpha 1
CHI3L2 chitinase 3-like 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
MMD monocyte to macrophage differentiation-associated
NQO1 NAD(P)H dehydrogenase, quinone 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCND2 cyclin D2
DLK1 delta-like 1 homolog (Drosophila)
F3 coagulation factor III (thromboplastin, tissue factor)
HOPX HOP homeobox
IFITM1 interferon induced transmembrane protein 1
KRT1 keratin 1, type II
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PTCH1 patched 1
SEPP1 selenoprotein P, plasma, 1
TNS3 tensin 3
VDAC1 voltage-dependent anion channel 1
ZIC1 Zic family member 1