BRD-K11927976_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

244 genes differentially expressed following the BRD-K11927976_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AEBP1 AE binding protein 1
ARL4C ADP-ribosylation factor-like 4C
BTG3 BTG family, member 3
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CDH13 cadherin 13
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK14 cyclin-dependent kinase 14
CECR1 cat eye syndrome chromosome region, candidate 1
CIB2 calcium and integrin binding family member 2
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EREG epiregulin
ETHE1 ethylmalonic encephalopathy 1
FABP4 fatty acid binding protein 4, adipocyte
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FST follistatin
FSTL1 follistatin-like 1
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GPC4 glypican 4
GPM6A glycoprotein M6A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
IDO1 indoleamine 2,3-dioxygenase 1
IL13RA1 interleukin 13 receptor, alpha 1
INA internexin neuronal intermediate filament protein, alpha
LAMP3 lysosomal-associated membrane protein 3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MMP10 matrix metallopeptidase 10
MSN moesin
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NID1 nidogen 1
NMU neuromedin U
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEA15 phosphoprotein enriched in astrocytes 15
PERP PERP, TP53 apoptosis effector
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSG5 pregnancy specific beta-1-glycoprotein 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBKS ribokinase
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGR SH3 domain binding glutamate-rich protein
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TRHDE thyrotropin-releasing hormone degrading enzyme
TSPAN12 tetraspanin 12
VGLL1 vestigial-like family member 1
VIM vimentin

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADGRG2 adhesion G protein-coupled receptor G2
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMT1 acidic residue methyltransferase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BARD1 BRCA1 associated RING domain 1
BLCAP bladder cancer associated protein
BRD2 bromodomain containing 2
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CAPN6 calpain 6
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DICER1 dicer 1, ribonuclease type III
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFNA4 ephrin-A4
EIF4B eukaryotic translation initiation factor 4B
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FAM208B family with sequence similarity 208, member B
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GEMIN4 gem (nuclear organelle) associated protein 4
GOSR1 golgi SNAP receptor complex member 1
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INSIG1 insulin induced gene 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0485 uncharacterized LOC57235
KIN Kin17 DNA and RNA binding protein
KIZ kizuna centrosomal protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
METTL18 methyltransferase like 18
MGP matrix Gla protein
MRFAP1L1 Morf4 family associated protein 1-like 1
MT1X metallothionein 1X
MTF2 metal response element binding transcription factor 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NOTCH2NL notch 2 N-terminal like
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
RANBP2 RAN binding protein 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RHOB ras homolog family member B
RMI1 RecQ mediated genome instability 1
RNF111 ring finger protein 111
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
SAP30 Sin3A-associated protein, 30kDa
SCAF8 SR-related CTD-associated factor 8
SCYL3 SCY1-like 3 (S. cerevisiae)
SESN1 sestrin 1
SETD5 SET domain containing 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNRPE small nuclear ribonucleoprotein polypeptide E
SOCS1 suppressor of cytokine signaling 1
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPTAN1 spectrin, alpha, non-erythrocytic 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX2 T-box 2
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK2 tousled-like kinase 2
TM2D3 TM2 domain containing 3
TMX4 thioredoxin-related transmembrane protein 4
TOB1 transducer of ERBB2, 1
TRIM32 tripartite motif containing 32
TRIM8 tripartite motif containing 8
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TTF1 transcription termination factor, RNA polymerase I
TXLNA taxilin alpha
VEZF1 vascular endothelial zinc finger 1
VGLL4 vestigial-like family member 4
WDR37 WD repeat domain 37
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZBTB1 zinc finger and BTB domain containing 1
ZMYM2 zinc finger, MYM-type 2
ZNF443 zinc finger protein 443