BRD-K11927976_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

260 genes differentially expressed following the BRD-K11927976_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPTL2 angiopoietin-like 2
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSK cathepsin K
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA4 defensin, alpha 4, corticostatin
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
FPR3 formyl peptide receptor 3
FST follistatin
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP1 lysosomal-associated membrane protein 1
LAMP3 lysosomal-associated membrane protein 3
LCK LCK proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MPP1 membrane protein, palmitoylated 1, 55kDa
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
NTS neurotensin
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PCDH17 protocadherin 17
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PEA15 phosphoprotein enriched in astrocytes 15
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
TGFA transforming growth factor, alpha
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
UGP2 UDP-glucose pyrophosphorylase 2
VCAN versican
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XYLT1 xylosyltransferase I
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
AGR2 anterior gradient 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMT1 acidic residue methyltransferase 1
ASNSD1 asparagine synthetase domain containing 1
ATMIN ATM interactor
AURKA aurora kinase A
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CHPT1 choline phosphotransferase 1
CLU clusterin
COIL coilin
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EHD1 EH-domain containing 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESR1 estrogen receptor 1
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JMJD6 jumonji domain containing 6
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KIAA0101 KIAA0101
KIN Kin17 DNA and RNA binding protein
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT7 keratin 7, type II
KYNU kynureninase
LARP4B La ribonucleoprotein domain family, member 4B
MAPK6 mitogen-activated protein kinase 6
MED1 mediator complex subunit 1
MELK maternal embryonic leucine zipper kinase
MLPH melanophilin
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK2 polo-like kinase 2
PNMA1 paraneoplastic Ma antigen 1
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRPF4B pre-mRNA processing factor 4B
PTGES prostaglandin E synthase
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RET ret proto-oncogene
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
SCAF8 SR-related CTD-associated factor 8
SERBP1 SERPINE1 mRNA binding protein 1
SFN stratifin
SIX1 SIX homeobox 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRSF11 serine/arginine-rich splicing factor 11
SUCO SUN domain containing ossification factor
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TDG thymine-DNA glycosylase
TFF1 trefoil factor 1
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM243 transmembrane protein 243, mitochondrial
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPYL1 TSPY-like 1
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
URI1 URI1, prefoldin-like chaperone
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZDHHC7 zinc finger, DHHC-type containing 7