BRD-K11927976_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K11927976_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACPP acid phosphatase, prostate
ADD3 adducin 3 (gamma)
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
C2CD2 C2 calcium-dependent domain containing 2
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEP70 centrosomal protein 70kDa
CHMP4A charged multivesicular body protein 4A
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CKB creatine kinase, brain
COL5A2 collagen, type V, alpha 2
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CTSV cathepsin V
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
EID1 EP300 interacting inhibitor of differentiation 1
ERLIN2 ER lipid raft associated 2
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FOXF1 forkhead box F1
FRY furry homolog (Drosophila)
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSTP1 glutathione S-transferase pi 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HTRA1 HtrA serine peptidase 1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IL7R interleukin 7 receptor
INHBA inhibin, beta A
ITM2A integral membrane protein 2A
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT4 keratin 4, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LIN28A lin-28 homolog A (C. elegans)
LRRC17 leucine rich repeat containing 17
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MN1 meningioma (disrupted in balanced translocation) 1
MSN moesin
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NLRP2 NLR family, pyrin domain containing 2
NPR3 natriuretic peptide receptor 3
NTS neurotensin
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PERP PERP, TP53 apoptosis effector
PFKM phosphofructokinase, muscle
PLCB4 phospholipase C, beta 4
PRKCB protein kinase C, beta
PRKCH protein kinase C, eta
PTGES prostaglandin E synthase
RGS1 regulator of G-protein signaling 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLIT2 slit homolog 2 (Drosophila)
SORD sorbitol dehydrogenase
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM35 transmembrane protein 35
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
UGP2 UDP-glucose pyrophosphorylase 2
VIM vimentin

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ARF6 ADP-ribosylation factor 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATXN7 ataxin 7
AURKA aurora kinase A
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK12 cyclin-dependent kinase 12
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COL9A3 collagen, type IX, alpha 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTSH cathepsin H
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
ELOVL2 ELOVL fatty acid elongase 2
F5 coagulation factor V (proaccelerin, labile factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FAM53C family with sequence similarity 53, member C
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GNAS GNAS complex locus
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JMJD6 jumonji domain containing 6
KIF2A kinesin heavy chain member 2A
KIF2C kinesin family member 2C
KRT10 keratin 10, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MSH6 mutS homolog 6
MSX1 msh homeobox 1
MTCL1 microtubule crosslinking factor 1
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PLK2 polo-like kinase 2
POU2AF1 POU class 2 associating factor 1
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100P S100 calcium binding protein P
SCAF8 SR-related CTD-associated factor 8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD5 SET domain containing 5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STOM stomatin
SUCO SUN domain containing ossification factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
USP3 ubiquitin specific peptidase 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCPKMT valosin containing protein lysine (K) methyltransferase
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XBP1 X-box binding protein 1
ZDHHC7 zinc finger, DHHC-type containing 7