BRD-K11795542_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

305 genes differentially expressed following the BRD-K11795542_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
AQP9 aquaporin 9
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CTGF connective tissue growth factor
CYB5A cytochrome b5 type A (microsomal)
DHCR24 24-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
FHOD3 formin homology 2 domain containing 3
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GPM6A glycoprotein M6A
GSTA1 glutathione S-transferase alpha 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPSE heparanase
IDO1 indoleamine 2,3-dioxygenase 1
INA internexin neuronal intermediate filament protein, alpha
INSM1 insulinoma-associated 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MSN moesin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NDRG1 N-myc downstream regulated 1
NEB nebulin
NELL2 NEL-like 2 (chicken)
NID1 nidogen 1
NMU neuromedin U
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEA15 phosphoprotein enriched in astrocytes 15
PGK1 phosphoglycerate kinase 1
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRTN3 proteinase 3
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
SYT1 synaptotagmin I
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TPGS2 tubulin polyglutamylase complex subunit 2
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
VAMP3 vesicle-associated membrane protein 3
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADGRG2 adhesion G protein-coupled receptor G2
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP12 Rho GTPase activating protein 12
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ASF1A anti-silencing function 1A histone chaperone
ASXL1 additional sex combs like transcriptional regulator 1
ASXL2 additional sex combs like transcriptional regulator 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
B3GNT1
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BARD1 BRCA1 associated RING domain 1
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL7B B-cell CLL/lymphoma 7B
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BRD3 bromodomain containing 3
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK13 cyclin-dependent kinase 13
CDK7 cyclin-dependent kinase 7
CDKN3 cyclin-dependent kinase inhibitor 3
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CEP350 centrosomal protein 350kDa
CEP76 centrosomal protein 76kDa
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
EXOSC4 exosome component 4
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GGNBP2 gametogenetin binding protein 2
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
H2AFX H2A histone family, member X
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS6 integrator complex subunit 6
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIAA0485 uncharacterized LOC57235
KIN Kin17 DNA and RNA binding protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LARP4B La ribonucleoprotein domain family, member 4B
LMO2 LIM domain only 2 (rhombotin-like 1)
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAPK6 mitogen-activated protein kinase 6
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MEPCE methylphosphate capping enzyme
METTL18 methyltransferase like 18
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFIL3 nuclear factor, interleukin 3 regulated
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NOTCH2NL notch 2 N-terminal like
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCM1 pericentriolar material 1
PDCD6 programmed cell death 6
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G15 phospholipase A2, group XV
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSPC1 paraspeckle component 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PURA purine-rich element binding protein A
RAB5A RAB5A, member RAS oncogene family
RABGAP1 RAB GTPase activating protein 1
RABIF RAB interacting factor
RAD9A RAD9 homolog A (S. pombe)
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM15 RNA binding motif protein 15
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
RUFY3 RUN and FYVE domain containing 3
S100A11 S100 calcium binding protein A11
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SCAND1 SCAN domain containing 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SESN1 sestrin 1
SETD2 SET domain containing 2
SETD5 SET domain containing 5
SETX senataxin
SFN stratifin
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SIX1 SIX homeobox 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SPATA2 spermatogenesis associated 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TACC1 transforming, acidic coiled-coil containing protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TBP TATA box binding protein
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDG thymine-DNA glycosylase
TDP1 tyrosyl-DNA phosphodiesterase 1
TESC tescalcin
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM185B transmembrane protein 185B
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOP2B topoisomerase (DNA) II beta 180kDa
TRIM33 tripartite motif containing 33
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBE3A ubiquitin protein ligase E3A
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WDR37 WD repeat domain 37
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZBTB1 zinc finger and BTB domain containing 1
ZMYM2 zinc finger, MYM-type 2
ZNF281 zinc finger protein 281
ZNF443 zinc finger protein 443