BRD-K11663430_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

209 genes differentially expressed following the BRD-K11663430_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CCND3 cyclin D3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CKB creatine kinase, brain
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CYLD cylindromatosis (turban tumor syndrome)
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
EDNRA endothelin receptor type A
ENAH enabled homolog (Drosophila)
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM171A1 family with sequence similarity 171, member A1
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GPM6A glycoprotein M6A
GRK5 G protein-coupled receptor kinase 5
GSDMB gasdermin B
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
HEPH hephaestin
HPCAL1 hippocalcin-like 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IL2RG interleukin 2 receptor, gamma
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KIAA0355 KIAA0355
KIF5C kinesin family member 5C
LAPTM5 lysosomal protein transmembrane 5
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS4 lectin, galactoside-binding, soluble, 4
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MSN moesin
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NIT1 nitrilase 1
NOSIP nitric oxide synthase interacting protein
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OPN3 opsin 3
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCP4 Purkinje cell protein 4
PCSK5 proprotein convertase subtilisin/kexin type 5
PEG10 paternally expressed 10
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PPARD peroxisome proliferator-activated receptor delta
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PRUNE2 prune homolog 2 (Drosophila)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
REG3A regenerating islet-derived 3 alpha
RFTN1 raftlin, lipid raft linker 1
RGS16 regulator of G-protein signaling 16
RNF167 ring finger protein 167
ROGDI rogdi homolog (Drosophila)
RORA RAR-related orphan receptor A
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCE sarcoglycan, epsilon
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SOBP sine oculis binding protein homolog (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SST somatostatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
SYNDIG1 synapse differentiation inducing 1
TBXA2R thromboxane A2 receptor
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM110 transmembrane protein 110
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM255A transmembrane protein 255A
TRIM2 tripartite motif containing 2
TUBA4A tubulin, alpha 4a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARGLU1 arginine and glutamate rich 1
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BICD1 bicaudal D homolog 1 (Drosophila)
C6ORF62 chromosome 6 open reading frame 62
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCND1 cyclin D1
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL5A2 collagen, type V, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYAB crystallin, alpha B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTD dCMP deaminase
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ESR1 estrogen receptor 1
FAM20B family with sequence similarity 20, member B
FAM57A family with sequence similarity 57, member A
FBXO11 F-box protein 11
FZD6 frizzled class receptor 6
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KIF14 kinesin family member 14
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LOX lysyl oxidase
LPAR2 lysophosphatidic acid receptor 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
MREG melanoregulin
MTMR1 myotubularin related protein 1
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PAK1IP1 PAK1 interacting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
RBBP8 retinoblastoma binding protein 8
RBM47 RNA binding motif protein 47
S100A2 S100 calcium binding protein A2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SPDEF SAM pointed domain containing ETS transcription factor
STC2 stanniocalcin 2
STXBP2 syntaxin binding protein 2
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
THBS4 thrombospondin 4
TMPO thymopoietin
TNS3 tensin 3
TWIST1 twist family bHLH transcription factor 1
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP34 ubiquitin specific peptidase 34
VRK2 vaccinia related kinase 2
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB20 zinc finger and BTB domain containing 20