BRD-K11663430_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K11663430_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
ACOT7 acyl-CoA thioesterase 7
APOD apolipoprotein D
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BBX bobby sox homolog (Drosophila)
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND3 cyclin D3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN10 claudin 10
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CYBB cytochrome b-245, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EIF5A eukaryotic translation initiation factor 5A
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMG20B high mobility group 20B
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSDL2 hydroxysteroid dehydrogenase like 2
ICAM1 intercellular adhesion molecule 1
IFI6 interferon, alpha-inducible protein 6
IGL immunoglobulin lambda locus
ITM2A integral membrane protein 2A
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LTF lactotransferrin
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NOSIP nitric oxide synthase interacting protein
NT5E 5'-nucleotidase, ecto (CD73)
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PRKCD protein kinase C, delta
RGS10 regulator of G-protein signaling 10
SCPEP1 serine carboxypeptidase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNN stannin
SOBP sine oculis binding protein homolog (Drosophila)
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STXBP1 syntaxin binding protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TPD52 tumor protein D52
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA1 annexin A1
APOA2 apolipoprotein A-II
APP amyloid beta (A4) precursor protein
ATF5 activating transcription factor 5
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AUTS2 autism susceptibility candidate 2
CCDC86 coiled-coil domain containing 86
CST3 cystatin C
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GPX2 glutathione peroxidase 2
HMGB2 high mobility group box 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KEAP1 kelch-like ECH-associated protein 1
LAD1 ladinin 1
LAPTM4B lysosomal protein transmembrane 4 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MSLN mesothelin
PGC progastricsin (pepsinogen C)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PRR7 proline rich 7 (synaptic)
RAD23B RAD23 homolog B (S. cerevisiae)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A10 S100 calcium binding protein A10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
TF transferrin
UBE2E3 ubiquitin-conjugating enzyme E2E 3
XIST X inactive specific transcript (non-protein coding)