BRD-K11663430_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K11663430_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADGRG6 adhesion G protein-coupled receptor G6
AGTPBP1 ATP/GTP binding protein 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5 arachidonate 5-lipoxygenase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BLCAP bladder cancer associated protein
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND3 cyclin D3
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CIB1 calcium and integrin binding 1 (calmyrin)
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DGKA diacylglycerol kinase, alpha 80kDa
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EDNRA endothelin receptor type A
EFHD1 EF-hand domain family, member D1
F2RL1 coagulation factor II (thrombin) receptor-like 1
G6PD glucose-6-phosphate dehydrogenase
GLRX glutaredoxin (thioltransferase)
HN1 hematological and neurological expressed 1
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LEF1 lymphoid enhancer-binding factor 1
LYZ lysozyme
MAP7 microtubule-associated protein 7
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NIT1 nitrilase 1
OLFM4 olfactomedin 4
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
RGS13 regulator of G-protein signaling 13
RNASET2 ribonuclease T2
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A1 solute carrier family 38, member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRPX sushi-repeat containing protein, X-linked
STK17A serine/threonine kinase 17a
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM176B transmembrane protein 176B
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2B tubulin, beta 2B class IIb
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP8 A kinase (PRKA) anchor protein 8
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ATP13A3 ATPase type 13A3
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
CCND1 cyclin D1
CELF2 CUGBP, Elav-like family member 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CST3 cystatin C
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EMP1 epithelial membrane protein 1
FAM57A family with sequence similarity 57, member A
FGFR2 fibroblast growth factor receptor 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLDC glycine dehydrogenase (decarboxylating)
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXB7 homeobox B7
ILF3 interleukin enhancer binding factor 3, 90kDa
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KLK10 kallikrein-related peptidase 10
KRT6A keratin 6A, type II
LOX lysyl oxidase
LPL lipoprotein lipase
LRRC41 leucine rich repeat containing 41
LY6E lymphocyte antigen 6 complex, locus E
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MEPCE methylphosphate capping enzyme
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
NRN1 neuritin 1
OBSL1 obscurin-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PUF60 poly-U binding splicing factor 60KDa
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RPL10 ribosomal protein L10
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SORBS2 sorbin and SH3 domain containing 2
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARBP1 TAR (HIV-1) RNA binding protein 1
THBS1 thrombospondin 1
TWIST1 twist family bHLH transcription factor 1
TXLNA taxilin alpha
TYMS thymidylate synthetase
UBE2G2 ubiquitin-conjugating enzyme E2G 2
ZBED1 zinc finger, BED-type containing 1
ZMYND11 zinc finger, MYND-type containing 11