BRD-K11558771_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K11558771_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDOA aldolase A, fructose-bisphosphate
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP29 Rho GTPase activating protein 29
AZU1 azurocidin 1
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG1 B-cell translocation gene 1, anti-proliferative
BZW2 basic leucine zipper and W2 domains 2
C14ORF132 chromosome 14 open reading frame 132
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
CLU clusterin
DCN decorin
ELANE elastase, neutrophil expressed
F3 coagulation factor III (thromboplastin, tissue factor)
FAM171A1 family with sequence similarity 171, member A1
FAM69A family with sequence similarity 69, member A
FN1 fibronectin 1
FNBP1L formin binding protein 1-like
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LRRC16A leucine rich repeat containing 16A
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
MYH10 myosin, heavy chain 10, non-muscle
PAX5 paired box 5
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SP110 SP110 nuclear body protein
SRPX sushi-repeat containing protein, X-linked
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ADI1 acireductone dioxygenase 1
ARL4A ADP-ribosylation factor-like 4A
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CADM1 cell adhesion molecule 1
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
COL1A2 collagen, type I, alpha 2
CRYAB crystallin, alpha B
DUT deoxyuridine triphosphatase
EFS embryonal Fyn-associated substrate
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FOSL2 FOS-like antigen 2
GOLGA8H golgin A8 family, member H
GPR183 G protein-coupled receptor 183
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLF hepatic leukemia factor
ILF3 interleukin enhancer binding factor 3, 90kDa
IQGAP2 IQ motif containing GTPase activating protein 2
KEAP1 kelch-like ECH-associated protein 1
KLK11 kallikrein-related peptidase 11
KRT16 keratin 16, type I
KRT17 keratin 17, type I
LDLR low density lipoprotein receptor
LY6D lymphocyte antigen 6 complex, locus D
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MDFIC MyoD family inhibitor domain containing
MGLL monoglyceride lipase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OSBPL3 oxysterol binding protein-like 3
PLK1 polo-like kinase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)