BRD-K11540476_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K11540476_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
APP amyloid beta (A4) precursor protein
ASGR2 asialoglycoprotein receptor 2
BCL3 B-cell CLL/lymphoma 3
CALR calreticulin
CCDC85B coiled-coil domain containing 85B
CCL4 chemokine (C-C motif) ligand 4
CCNF cyclin F
CCR2 chemokine (C-C motif) receptor 2
CD8A CD8a molecule
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
COLEC12 collectin sub-family member 12
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GNLY granulysin
HMGA1 high mobility group AT-hook 1
IL32 interleukin 32
KLHL9 kelch-like family member 9
LGALS1 lectin, galactoside-binding, soluble, 1
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MMP11 matrix metallopeptidase 11
NEBL nebulette
NKG7 natural killer cell granule protein 7
NRGN neurogranin (protein kinase C substrate, RC3)
NSDHL NAD(P) dependent steroid dehydrogenase-like
PITX1 paired-like homeodomain 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POPDC3 popeye domain containing 3
PRSS3 protease, serine, 3
PRUNE2 prune homolog 2 (Drosophila)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF167 ring finger protein 167
RRBP1 ribosome binding protein 1
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
STX1A syntaxin 1A (brain)
TBCB tubulin folding cofactor B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTN1 actinin, alpha 1
ADI1 acireductone dioxygenase 1
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ARMCX2 armadillo repeat containing, X-linked 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BASP1 brain abundant, membrane attached signal protein 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CCL19 chemokine (C-C motif) ligand 19
CCND3 cyclin D3
CD52 CD52 molecule
CDK4 cyclin-dependent kinase 4
CLINT1 clathrin interactor 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLD dihydrolipoamide dehydrogenase
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPHA3 EPH receptor A3
FABP4 fatty acid binding protein 4, adipocyte
GPC4 glypican 4
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEATR1 HEAT repeat containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXD1 homeobox D1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IRS1 insulin receptor substrate 1
KIF2C kinesin family member 2C
KLHDC2 kelch domain containing 2
LAMP3 lysosomal-associated membrane protein 3
LEF1 lymphoid enhancer-binding factor 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHFP lipoma HMGIC fusion partner
LY96 lymphocyte antigen 96
MET MET proto-oncogene, receptor tyrosine kinase
METTL21B methyltransferase like 21B
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP62 nucleoporin 62kDa
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PLS3 plastin 3
PPARG peroxisome proliferator-activated receptor gamma
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRKD3 protein kinase D3
PRPF4 pre-mRNA processing factor 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RBM15B RNA binding motif protein 15B
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS13 regulator of G-protein signaling 13
RGS5 regulator of G-protein signaling 5
RRP1B ribosomal RNA processing 1B
SAP30 Sin3A-associated protein, 30kDa
SC5D sterol-C5-desaturase
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SKP1 S-phase kinase-associated protein 1
SMAD3 SMAD family member 3
SMS spermine synthase
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYBU syntabulin (syntaxin-interacting)
TAGLN transgelin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THUMPD1 THUMP domain containing 1
TM4SF1 transmembrane 4 L six family member 1
TMEM106B transmembrane protein 106B
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX thymocyte selection-associated high mobility group box
TSPAN31 tetraspanin 31
TXNDC9 thioredoxin domain containing 9
TYRP1 tyrosinase-related protein 1
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
WT1 Wilms tumor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFPM2 zinc finger protein, FOG family member 2
ZMYM2 zinc finger, MYM-type 2