BRD-K10995081_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K10995081_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CST1 cystatin SN
CTGF connective tissue growth factor
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPR87 G protein-coupled receptor 87
GRN granulin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICA1 islet cell autoantigen 1, 69kDa
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL32 interleukin 32
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
NAV2 neuron navigator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPAS2 neuronal PAS domain protein 2
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPAP2C phosphatidic acid phosphatase type 2C
PRSS23 protease, serine, 23
PSAP prosaposin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAGD Ras-related GTP binding D
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHMP4A charged multivesicular body protein 4A
DCXR dicarbonyl/L-xylulose reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
E2F8 E2F transcription factor 8
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
MCM10 minichromosome maintenance complex component 10
MKI67 marker of proliferation Ki-67
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC2 structural maintenance of chromosomes 2
SPC25 SPC25, NDC80 kinetochore complex component
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
ZWINT ZW10 interacting kinetochore protein