BRD-K10995081_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K10995081_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDOC aldolase C, fructose-bisphosphate
ALOX15B arachidonate 15-lipoxygenase, type B
APOD apolipoprotein D
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA12 carbonic anhydrase XII
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
COBL cordon-bleu WH2 repeat protein
COL9A3 collagen, type IX, alpha 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP2 epithelial membrane protein 2
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GMDS GDP-mannose 4,6-dehydratase
GPX3 glutathione peroxidase 3
HDAC6 histone deacetylase 6
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
KLK11 kallikrein-related peptidase 11
LPL lipoprotein lipase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
METTL7A methyltransferase like 7A
NEBL nebulette
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
OSBPL9 oxysterol binding protein-like 9
PDPN podoplanin
PIP prolactin-induced protein
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PROM1 prominin 1
PRSS21 protease, serine, 21 (testisin)
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
RAB40B RAB40B, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
SSBP2 single-stranded DNA binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TECR trans-2,3-enoyl-CoA reductase
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMSB15A thymosin beta 15a
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ATF3 activating transcription factor 3
CALD1 caldesmon 1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CELF2 CUGBP, Elav-like family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
CKAP4 cytoskeleton-associated protein 4
CYR61 cysteine-rich, angiogenic inducer, 61
FABP7 fatty acid binding protein 7, brain
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FZD6 frizzled class receptor 6
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JAG1 jagged 1
KRT13 keratin 13, type I
LY96 lymphocyte antigen 96
MARCKS myristoylated alanine-rich protein kinase C substrate
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MRPS2 mitochondrial ribosomal protein S2
MTERF3 mitochondrial transcription termination factor 3
NNMT nicotinamide N-methyltransferase
PAEP progestagen-associated endometrial protein
PDLIM3 PDZ and LIM domain 3
PDLIM5 PDZ and LIM domain 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PLN phospholamban
RGS5 regulator of G-protein signaling 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SST somatostatin
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM47 transmembrane protein 47
TOR1A torsin family 1, member A (torsin A)
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
TXNDC9 thioredoxin domain containing 9
UPP1 uridine phosphorylase 1
XIST X inactive specific transcript (non-protein coding)